{"id":"W2760905236","doi":"10.1096/fj.201700599rr","title":"Identification and characterization of hydrophobic gate residues in TRP channels","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; Biophysics; Gating; Xenopus; Transient receptor potential channel; Hydrophobic effect; Residue (chemistry); Stereochemistry; Crystallography; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004223094,0.00005438443,0.00008356858,0.00007100696,0.0004371212,0.0001586952,0.000248285,0.00002784991,0.00002372028],"category_scores_gemma":[0.0001016219,0.00003437241,0.0000237944,0.00004746113,0.0001374687,0.0002799418,0.00004111432,0.0001269804,0.000007705135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009986796,"about_ca_system_score_gemma":0.00001385757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000987035,"about_ca_topic_score_gemma":0.000002288181,"domain_scores_codex":[0.9993606,0.0001012836,0.0001983134,0.0000953394,0.000139028,0.000105472],"domain_scores_gemma":[0.9994235,0.00002742259,0.0003603055,0.000132426,0.00002380839,0.00003253414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001852742,0.00001346888,0.0002933676,0.000004661474,9.11361e-7,0.000003656543,0.0007763557,0.00001719392,0.9978889,0.00006961628,0.000007050238,0.0009063269],"study_design_scores_gemma":[0.0001991003,0.00002270508,0.01725369,0.00004107217,0.0000032551,0.00005138034,0.00004410388,0.00115126,0.980607,0.0005507487,0.00003394966,0.00004174965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979639,0.00001543843,0.00004553936,0.001048866,0.0007555489,0.00007633126,0.000004183416,0.000004150682,0.00008602218],"genre_scores_gemma":[0.9984449,0.000563875,0.000001777899,0.00003909265,0.0001706108,0.000001702003,5.552543e-7,0.000005966575,0.000771484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01728188,"threshold_uncertainty_score":0.3362027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310004534046663,"score_gpt":0.273938968395203,"score_spread":0.2408389230547364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}