{"id":"W2760905236","doi":"10.1096/fj.201700599rr","title":"Identification and characterization of hydrophobic gate residues in TRP channels","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; Biophysics; Gating; Xenopus; Transient receptor potential channel; Hydrophobic effect; Residue (chemistry); Stereochemistry; Crystallography; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043497,0.0001477857,0.0001944744,0.000107374,0.0001077248,0.0001555668,0.0001107452,0.0001986034,0.0003448208],"category_scores_gemma":[0.0002402738,0.00006718008,0.0001736459,0.0001068702,0.0001825663,0.0002086693,0.0001559708,0.0002497406,0.0001345376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007164446,"about_ca_system_score_gemma":0.0001054905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001359129,"about_ca_topic_score_gemma":0.000120362,"domain_scores_codex":[0.9999336,0.000009992998,0.000005684464,0.00001644472,0.00002033711,0.00001382519],"domain_scores_gemma":[0.9998599,0.00003052531,0.00004547741,0.00001696895,0.00001785794,0.00002912628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004436616,0.000006488112,0.0003053777,0.00001708697,0.000001846389,0.00004471306,0.000008754672,0.00006470783,0.9986911,0.00005436198,0.000005130943,0.0007558885],"study_design_scores_gemma":[0.00001372151,0.0002275132,0.009333269,0.000005995421,0.00001694461,0.0004598228,0.00003851068,0.002094972,0.9866758,0.0001317087,0.0009933535,0.000008400214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965585,0.0001644075,0.002919699,0.00001608218,0.000005688155,0.00001175823,0.00007484848,0.000008916158,0.0002401281],"genre_scores_gemma":[0.9957755,0.0001743217,0.003458088,0.00002374417,0.000005297389,0.00001269448,0.0002576979,0.000009750035,0.0002828058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003448208,"threshold_uncertainty_score":0.001153529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310004534046663,"score_gpt":0.273938968395203,"score_spread":0.2408389230547364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}