{"id":"W2760959429","doi":"10.1093/annonc/mdx363.043","title":"EGFR copy number aberrations detected in cfDNA from advanced NSCLC patients","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"T790M; Medicine; KRAS; Neuroblastoma RAS viral oncogene homolog; Epidermal growth factor receptor; Liquid biopsy; Exon; Cancer research; Mutation; Deep sequencing; Osimertinib; Resistance mutation; Oncology; Gefitinib; Internal medicine; Cancer; Gene; Polymerase chain reaction; Biology; Erlotinib; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144361,0.0001707687,0.0002269098,0.00106311,0.0004118881,0.0005855776,0.0001968784,0.0004810021,0.003001267],"category_scores_gemma":[0.0009157559,0.0001388697,0.0001835202,0.0005070874,0.0002395477,0.0002318356,0.0002784878,0.0002256445,0.0003693551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005200637,"about_ca_system_score_gemma":0.0003214841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006218357,"about_ca_topic_score_gemma":0.006881991,"domain_scores_codex":[0.9997744,0.000009361279,0.00002787854,0.00006280783,0.00007269136,0.00005286922],"domain_scores_gemma":[0.9998077,0.00006149176,0.00003273854,0.00001656389,0.00005422242,0.00002729992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00157351,0.00005709763,0.8377831,0.00009085509,0.0001082397,0.004084009,0.0004257578,0.0005018141,0.1250607,0.000273537,0.001322159,0.02871931],"study_design_scores_gemma":[0.00004028963,0.0003028491,0.9421045,0.00003076128,0.0001201062,0.01223791,0.0005525154,0.001373816,0.03580068,0.0003374224,0.007078786,0.00002031956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947739,0.0008389503,0.0002494679,0.00013783,0.00002897614,0.00001569727,0.00135977,0.00002075917,0.002574739],"genre_scores_gemma":[0.9977575,0.0001836102,0.000199177,0.00007122528,0.000009216089,0.000009476131,0.000740955,0.000004716963,0.001024163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006218357,"threshold_uncertainty_score":0.01236433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04919668819991271,"score_gpt":0.4522982180161306,"score_spread":0.4031015298162179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}