{"id":"W2761156597","doi":"10.1093/annonc/mdx374.019","title":"Immune profile analysis of head and neck squamous cell carcinoma before and after neoadjuvant treatment with the IRX-2 regimen","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Tumor microenvironment; Immune system; CD8; Head and neck squamous-cell carcinoma; Immunotherapy; Chemokine; Tumor-infiltrating lymphocytes; Cancer research; T cell; Oncology; Pathology; Internal medicine; Immunology; Cancer; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374507,0.000102682,0.0003117961,0.0002527579,0.0001727255,0.0002608554,0.00009815367,0.0001909104,0.001256461],"category_scores_gemma":[0.0004067148,0.00006432887,0.0002339914,0.0002426272,0.0001338221,0.0001759458,0.0000950795,0.0003258624,0.0002195812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336343,"about_ca_system_score_gemma":0.0002286603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007812559,"about_ca_topic_score_gemma":0.001038299,"domain_scores_codex":[0.9998733,0.00002014189,0.000009364312,0.00002545566,0.00002722537,0.00004448548],"domain_scores_gemma":[0.9998456,0.00004219001,0.00003220424,0.00001273838,0.00002874791,0.00003848665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02834756,0.001667904,0.6655633,0.0001984164,0.0002978748,0.00180591,0.0005898303,0.000771301,0.2262556,0.0001459614,0.001286209,0.07307009],"study_design_scores_gemma":[0.00006265443,0.005656333,0.978929,0.00001084496,0.0001469319,0.0009495359,0.0003332075,0.0005978525,0.01102948,0.00006145478,0.002208016,0.00001473275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987096,0.0003839115,0.00004867971,0.00002684905,0.00001539546,0.00001512695,0.0001359402,0.000002844,0.0006617497],"genre_scores_gemma":[0.9986482,0.0001533109,0.00006282245,0.00006219847,0.00001652192,0.00002177549,0.0003837001,0.000002149559,0.0006492879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256461,"threshold_uncertainty_score":0.00420332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03084945207482852,"score_gpt":0.3311706744289176,"score_spread":0.3003212223540891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}