{"id":"W2761230962","doi":"10.1016/j.jacc.2017.07.102","title":"GW28-e0806 Pyr1-Apelin 13 is a negative modulator of angiotensin II-mediated adverse myocardial hypertrophy, remodeling and fibrosis","year":2017,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Apelin; Medicine; Angiotensin II receptor type 1; Angiotensin II; Fibrosis; Blood pressure; Receptor; Internal medicine; Muscle hypertrophy; Renin–angiotensin system; Endocrinology; Angiotensin receptor; Cardiology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0009418174,0.0002209496,0.001763544,0.0002803535,0.0002294636,0.000005176661,0.0005160396,0.0002015848,0.00001661993],"category_scores_gemma":[0.004021368,0.0001414599,0.0007591429,0.0003133103,0.002826619,0.00009597179,0.0004709235,0.0007183856,0.000003218177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001164769,"about_ca_system_score_gemma":0.0006579063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476899,"about_ca_topic_score_gemma":0.000003088597,"domain_scores_codex":[0.9972935,0.0003403425,0.0009141641,0.0002556945,0.0008190201,0.0003772381],"domain_scores_gemma":[0.9956356,0.0005781095,0.001668083,0.000729909,0.001068807,0.0003194534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01980348,0.0002688259,0.08568253,0.0001809741,0.006628612,0.001015996,0.0008041508,0.001194717,0.8262275,0.00005548486,0.04253003,0.01560772],"study_design_scores_gemma":[0.01150053,0.008566572,0.9380378,0.0009808029,0.001953911,0.002815151,0.001860249,0.01155389,0.01165692,0.0007245133,0.009865508,0.0004841848],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880826,0.0004556327,0.0001616707,0.01018193,0.0003184229,0.0002968138,0.0001709825,0.000005958444,0.0003259979],"genre_scores_gemma":[0.9954211,0.0007977767,0.002566163,0.0004589029,0.0005492856,0.000001625413,0.00000131081,0.00003007932,0.0001737748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8523552,"threshold_uncertainty_score":0.9998871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824480954967322,"score_gpt":0.292172488766444,"score_spread":0.2739276792167708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}