{"id":"W2761271661","doi":"10.1212/nxg.0000000000000194","title":"The Alzheimer's Disease Sequencing Project: Study design and sample selection","year":2017,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mailman School of Public Health, Columbia University; National Heart, Lung, and Blood Institute; National Institute on Aging; Perelman School of Medicine, University of Pennsylvania; University of California, San Diego; University College London; American Society for Bone and Mineral Research; Edward N. and Della L. Thome Memorial Foundation; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; School of Medicine, Indiana University; Denali Therapeutics; Massachusetts Institute of Technology; School of Medicine, Boston University; Rainwater Charitable Foundation; University of Florida; Case Western Reserve University; Cleveland Clinic; Harvard University; JPB Foundation; University of Chicago; Fidelity Foundation; University of Texas at Austin; National Institutes of Health; San Diego State University; CurePSP; University of Pennsylvania; University of Miami; McKnight Foundation; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research; Broad Institute; U.S. Department of Defense","keywords":"Disease; Dementia; Epidemiology; Alzheimer's disease; Gerontology; Medicine; Genetics; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969132,0.0001355768,0.0001393689,0.0000439619,0.001136088,0.00009397249,0.0001387219,0.00004806907,0.000006268406],"category_scores_gemma":[0.0003115314,0.00009255992,0.00003466967,0.00004224171,0.000251977,0.00004010941,0.0001142427,0.0001842715,0.00001055585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000142799,"about_ca_system_score_gemma":0.0003651067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001247364,"about_ca_topic_score_gemma":0.00004795608,"domain_scores_codex":[0.998792,0.0002119447,0.0001269772,0.0003176899,0.0002177036,0.0003336764],"domain_scores_gemma":[0.998787,0.0002678226,0.00007531995,0.000529072,0.00008950417,0.0002512501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001540989,0.0003136151,0.9868668,0.000006731158,0.002125169,0.0003570377,0.00011449,0.00003436228,0.00006932974,0.00001843074,0.0003190007,0.008234004],"study_design_scores_gemma":[0.002074173,0.003267715,0.9845182,0.000004331835,0.001602192,0.00006662684,0.00004771275,0.006785279,0.0003157903,0.0006892201,0.0005179632,0.000110806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919054,0.004751103,0.0001494985,0.001161148,0.00009751257,0.001805171,0.00000853636,0.00004038384,0.00008124725],"genre_scores_gemma":[0.9984493,0.0005841068,0.0004982257,0.0002003457,0.0001045734,0.0001255351,0.000003661039,0.00002275069,0.00001153889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008123198,"threshold_uncertainty_score":0.8737984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1007967827155688,"score_gpt":0.3678965035935682,"score_spread":0.2670997208779994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}