{"id":"W2761271661","doi":"10.1212/nxg.0000000000000194","title":"The Alzheimer's Disease Sequencing Project: Study design and sample selection","year":2017,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mailman School of Public Health, Columbia University; National Heart, Lung, and Blood Institute; National Institute on Aging; Perelman School of Medicine, University of Pennsylvania; University of California, San Diego; University College London; American Society for Bone and Mineral Research; Edward N. and Della L. Thome Memorial Foundation; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; School of Medicine, Indiana University; Denali Therapeutics; Massachusetts Institute of Technology; School of Medicine, Boston University; Rainwater Charitable Foundation; University of Florida; Case Western Reserve University; Cleveland Clinic; Harvard University; JPB Foundation; University of Chicago; Fidelity Foundation; University of Texas at Austin; National Institutes of Health; San Diego State University; CurePSP; University of Pennsylvania; University of Miami; McKnight Foundation; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research; Broad Institute; U.S. Department of Defense","keywords":"Disease; Dementia; Epidemiology; Alzheimer's disease; Gerontology; Medicine; Genetics; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01695332,0.002161656,0.002715502,0.001973203,0.001480939,0.001270042,0.002465272,0.001543612,0.008987417],"category_scores_gemma":[0.0183236,0.001577997,0.00072038,0.002938292,0.0008750519,0.0007134873,0.001793807,0.001187361,0.003402614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001157294,"about_ca_system_score_gemma":0.00413427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009616253,"about_ca_topic_score_gemma":0.01303104,"domain_scores_codex":[0.9910169,0.005245419,0.0008752818,0.00140831,0.00109577,0.0003583627],"domain_scores_gemma":[0.9951355,0.001254605,0.0005196593,0.0008866017,0.001548978,0.0006546347],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.072868,0.007964128,0.3397203,0.006836498,0.003460096,0.005357211,0.004453221,0.007948333,0.009346509,0.01104465,0.2748725,0.2561286],"study_design_scores_gemma":[0.0471194,0.02467804,0.4799296,0.002551539,0.00507411,0.004109841,0.001624935,0.02324304,0.003281586,0.01965045,0.3881802,0.0005572116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"methods","genre_scores_codex":[0.3092834,0.008410483,0.1100452,0.004103336,0.001528047,0.4308164,0.1189898,0.0008062363,0.01601722],"genre_scores_gemma":[0.2414076,0.00317928,0.0803472,0.005085755,0.0009726947,0.6101053,0.04876646,0.0003446357,0.009791131],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.9830467,"threshold_uncertainty_score":0.0896588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1007967827155688,"score_gpt":0.3678965035935682,"score_spread":0.2670997208779994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}