{"id":"W2761296662","doi":"10.1021/acs.cgd.7b00806","title":"Controlled Recrystallization of Tubular Vinpocetine Crystals with Increased Aqueous Dissolution Rate and <i>In Vivo</i> Bioavailability","year":2017,"lang":"en","type":"article","venue":"Crystal Growth & Design","topic":"Crystallization and Solubility Studies","field":"Materials Science","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Science Foundation of Tianjin City; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Bioavailability; Dissolution; Recrystallization (geology); Vinpocetine; In vivo; Chemistry; Micronization; Chromatography; Aqueous solution; Excipient; Solubility; Chemical engineering; Materials science; Pharmacology; Organic chemistry; Particle size","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088482,0.0002145401,0.00016074,0.00009935348,0.00007909097,0.0001811047,0.0001794058,0.0002020005,0.0004885696],"category_scores_gemma":[0.0002033304,0.0001309608,0.0001948417,0.00009656927,0.000126022,0.000159425,0.0001208836,0.0003016401,0.000149971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059353,"about_ca_system_score_gemma":0.0001403452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006954415,"about_ca_topic_score_gemma":0.001319981,"domain_scores_codex":[0.9999044,0.000008944464,0.000006647747,0.00002916583,0.00003145633,0.00001931347],"domain_scores_gemma":[0.9999144,0.00001473736,0.00003593609,0.000008460348,0.00001663042,0.000009845748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003112844,0.000008195034,0.00008708319,0.00001984895,0.000002767509,0.000029112,0.0000100128,0.0001231315,0.9981674,0.00005979315,0.00003331686,0.001428158],"study_design_scores_gemma":[0.000003932498,0.00009904904,0.000565143,0.000001323929,0.000003362117,0.00004868574,0.000005095518,0.0008989464,0.9976795,0.00000628942,0.0006867732,0.000001958153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992238,0.0004322648,0.005613388,0.00003906287,0.00001456445,0.00003424069,0.0001698543,0.0001324657,0.001326172],"genre_scores_gemma":[0.9902187,0.0004087288,0.007306638,0.00001702298,0.000004578781,0.00002431163,0.0001653987,0.0000553869,0.001799198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006954415,"threshold_uncertainty_score":0.001634479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974869979616564,"score_gpt":0.2441145881828954,"score_spread":0.2243658883867298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}