{"id":"W2761441866","doi":"10.1093/annonc/mdx365.027","title":"Progression-free survival (PFS) and site of first progression in HER2+ metastatic breast cancer (MBC) patients (pts) with (w) or without (w/o) brain metastases: A pooled analysis of tucatinib phase I studies","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Internal medicine; Metastatic breast cancer; Capecitabine; Progression-free survival; Gastroenterology; Neratinib; Oncology; Hazard ratio; Trastuzumab; Surgery; Cancer; Breast cancer; Chemotherapy; Confidence interval; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0038409,0.0009238793,0.003322253,0.001280179,0.0001881932,0.001066672,0.0004101181,0.0006252388,0.001251332],"category_scores_gemma":[0.003544782,0.0003999052,0.006876287,0.001530281,0.0002743249,0.0006257703,0.0005405467,0.0007806393,0.0001499007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004697284,"about_ca_system_score_gemma":0.0003645332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163388,"about_ca_topic_score_gemma":0.003191903,"domain_scores_codex":[0.9985567,0.0008159106,0.0001726302,0.0002297347,0.0001224853,0.0001025729],"domain_scores_gemma":[0.9983128,0.0008917398,0.0005042726,0.0001079592,0.00008256184,0.0001006166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.3616093,0.0003710771,0.1711905,0.008912159,0.3503069,0.0003067696,0.0001273951,0.006104971,0.008830261,0.000176226,0.002140768,0.08992358],"study_design_scores_gemma":[0.02608304,0.0271458,0.4741532,0.0006841659,0.4604465,0.0008765081,0.0002181291,0.002735508,0.002534617,0.0005723236,0.004431552,0.0001188882],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8935914,0.1014747,0.0006955902,0.0001661063,0.00008758581,0.0001208918,0.002740491,0.00004109906,0.001082163],"genre_scores_gemma":[0.9894058,0.008422987,0.0001994646,0.0001207064,0.00007550431,0.00005881174,0.00141649,0.00001040636,0.0002898072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0038409,"threshold_uncertainty_score":0.02031285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1033041298061386,"score_gpt":0.481935895723458,"score_spread":0.3786317659173193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}