{"id":"W2761515565","doi":"10.1002/cbic.201700450","title":"AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Chemistry; Circular dichroism; Duplex (building); Deoxyguanosine; Methylene; Stereochemistry; Nucleic Acid Denaturation; Linker; Denaturation (fissile materials); Alkylation; Biophysics; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745725,0.0003061034,0.000224202,0.000008590993,0.0005265691,0.0001507446,0.0009134184,0.0004403365,0.0001141527],"category_scores_gemma":[0.0001223303,0.0002419875,0.0001858431,0.00003605891,0.0004667305,0.00001129673,0.0003403543,0.0002375291,0.00002686677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002122513,"about_ca_system_score_gemma":0.0000800811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004297069,"about_ca_topic_score_gemma":0.000003572946,"domain_scores_codex":[0.998588,0.00001678,0.0001939246,0.0005789597,0.0002039542,0.0004183938],"domain_scores_gemma":[0.9980468,0.000007294251,0.000197685,0.001493277,0.0001012784,0.0001536274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009493365,0.00008420717,0.0003717373,0.00002273914,0.0001062849,0.000002158765,0.00005379619,3.166126e-7,0.9652557,0.000001497236,0.02600782,0.00799885],"study_design_scores_gemma":[0.0009257378,0.00004921632,0.004256275,0.00001354558,0.00003370172,0.00001662653,0.00002342025,0.00005162087,0.9664463,0.00004432787,0.02782865,0.0003105749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892245,0.0004386273,0.000118922,0.001768996,0.0001769609,0.0001483057,0.00007801469,0.00002982985,0.008015841],"genre_scores_gemma":[0.9914078,0.0001523283,0.00006457625,0.0005085766,0.0004461429,0.00002133351,0.00012998,0.00004377782,0.007225557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007688276,"threshold_uncertainty_score":0.9867965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098336082378386,"score_gpt":0.2620443721579386,"score_spread":0.2510610113341547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}