{"id":"W2761515565","doi":"10.1002/cbic.201700450","title":"AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Chemistry; Circular dichroism; Duplex (building); Deoxyguanosine; Methylene; Stereochemistry; Nucleic Acid Denaturation; Linker; Denaturation (fissile materials); Alkylation; Biophysics; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229929,0.0001917172,0.00008099644,0.0001094191,0.00004386753,0.0001557884,0.00008514417,0.0001409409,0.0007419013],"category_scores_gemma":[0.0001996231,0.00007559337,0.00008586512,0.00008745395,0.0001137946,0.0000737582,0.00008627863,0.0001514725,0.0002154928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000859227,"about_ca_system_score_gemma":0.00006154498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611277,"about_ca_topic_score_gemma":0.000198413,"domain_scores_codex":[0.9999146,0.00002175461,0.000006758314,0.00002198784,0.0000192011,0.00001557043],"domain_scores_gemma":[0.9998363,0.00005973398,0.00005084446,0.00001277919,0.00001491939,0.00002528616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002629782,0.000003740044,0.00009664115,0.000005970112,0.000001222915,0.000006738842,0.000004925533,0.0000303472,0.9995004,0.00001151414,0.000002813908,0.0003093452],"study_design_scores_gemma":[0.000001566103,0.0001004102,0.0006137509,0.000001106086,0.000002773762,0.00003019907,0.000003201884,0.0002710064,0.998809,0.00000485659,0.0001614935,6.497934e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986149,0.0002014733,0.0007856398,0.000008401287,0.000003622982,0.000003684454,0.00003261689,0.00002082502,0.0003288244],"genre_scores_gemma":[0.9990075,0.0001110622,0.0003918178,0.000006115315,0.000001395337,0.00000350145,0.00008234311,0.000004429567,0.0003916582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007419013,"threshold_uncertainty_score":0.002481878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098336082378386,"score_gpt":0.2620443721579386,"score_spread":0.2510610113341547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}