{"id":"W2761635900","doi":"10.1016/j.jchf.2017.08.013","title":"A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator","year":2017,"lang":"en","type":"review","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bayer","keywords":"Medicine; Heart failure; Cyclic guanosine monophosphate; Placebo; Internal medicine; Natriuretic peptide; Ejection fraction; Cardiology; Multicenter trial; Vasodilation; Atrial natriuretic peptide; Afterload; Randomized controlled trial; Pharmacology; Nitric oxide; Hemodynamics; Pathology; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00225091,0.0007490649,0.006762689,0.0001932163,0.0003407121,0.00006835688,0.0005109756,0.0005239067,0.0001365089],"category_scores_gemma":[0.0009075303,0.0003336734,0.002826215,0.0002253917,0.0005171836,0.0001016484,0.0005192928,0.0007270168,0.00002918262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001034169,"about_ca_system_score_gemma":0.0006813353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001583867,"about_ca_topic_score_gemma":0.00009656387,"domain_scores_codex":[0.9952262,0.001065776,0.001868308,0.0005974431,0.0007421235,0.0005001497],"domain_scores_gemma":[0.9950166,0.001182922,0.00141479,0.002010436,0.0001639022,0.0002113125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9625048,0.0006760823,0.00001382935,0.004864873,0.002698311,0.000007098603,0.0001026949,0.000003210404,0.000001994536,0.00009576322,0.007421739,0.02160957],"study_design_scores_gemma":[0.5072421,0.0001306929,0.000002677948,0.004741276,0.006133175,0.00001101403,0.000007557362,0.0000289837,0.000003143075,0.000002816201,0.4815601,0.0001364823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003568081,0.8630512,0.00001551506,0.01407243,0.003024704,0.1151327,0.00007513488,0.00009826613,0.0009619418],"genre_scores_gemma":[0.009186936,0.9685696,0.001856222,0.0002243827,0.000980338,0.003104933,0.00008676405,0.0002195029,0.01577131],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4741383,"threshold_uncertainty_score":0.9999115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312365210693205,"score_gpt":0.3639476734188145,"score_spread":0.3008240213118825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}