{"id":"W2761652264","doi":"10.1093/annonc/mdx372.059","title":"ARIEL4: An international, randomised phase 3 study of the PARP inhibitor rucaparib vs chemotherapy for the treatment of BRCA-mutated, relapsed, high-grade ovarian cancer","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; BRCA mutation; PARP inhibitor; Internal medicine; Oncology; Olaparib; Chemotherapy; Regimen; Ovarian cancer; Chemotherapy regimen; Cancer; Poly ADP ribose polymerase; Genetics; Biology; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00275625,0.002428272,0.003334668,0.0007471823,0.0004881537,0.001701709,0.001808599,0.002573805,0.0123822],"category_scores_gemma":[0.002598428,0.0009799686,0.003098931,0.0006716445,0.001635042,0.001747114,0.0006616193,0.006693061,0.001897673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001204251,"about_ca_system_score_gemma":0.001357173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001654458,"about_ca_topic_score_gemma":0.003785404,"domain_scores_codex":[0.9989962,0.0006164808,0.00003703579,0.0001263431,0.00006173446,0.0001622477],"domain_scores_gemma":[0.9987462,0.0004699468,0.0002370485,0.0001149521,0.0000497918,0.0003821285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708338,0.006891691,0.0003274077,0.0005241366,0.00107868,0.00003757607,0.00004441342,0.00064837,0.002221948,0.0001933667,0.001005852,0.01619274],"study_design_scores_gemma":[0.9438483,0.05334774,0.0007303515,0.00002469813,0.0003769034,0.0000333605,0.00002004519,0.0003570901,0.0002906114,0.0002092503,0.0007441186,0.0000175468],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734095,0.008366609,0.001513856,0.002141456,0.001462198,0.004485699,0.002878114,0.0003959216,0.005346527],"genre_scores_gemma":[0.9675747,0.00578363,0.003390317,0.002862908,0.001046674,0.005374586,0.00332547,0.0001476688,0.01049405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0123822,"threshold_uncertainty_score":0.04142261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1254102918649513,"score_gpt":0.4641550448215745,"score_spread":0.3387447529566232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}