{"id":"W2761656877","doi":"10.1038/cddis.2017.458","title":"BCR–ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy","year":2017,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Sociedade Beneficente Israelita Brasileira Albert Einstein; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Cancer Research Society; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; University of Toronto; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Myeloid leukemia; Cancer research; Biology; K562 cells; Carcinogenesis; breakpoint cluster region; Haematopoiesis; Tyrosine kinase; Chronic myelogenous leukemia; DNA methylation; Leukemia; Immunology; Signal transduction; Cell biology; Stem cell; Cancer; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007413,0.0001676525,0.0002814195,0.0001238663,0.0001231202,0.00003906909,0.00008170747,0.00007812824,0.00001542732],"category_scores_gemma":[0.0001948008,0.000152025,0.00004024372,0.00005834878,0.0000693496,0.000105344,0.0000660853,0.00006289754,0.00000853144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006771311,"about_ca_system_score_gemma":0.0008127323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003744008,"about_ca_topic_score_gemma":0.00005019486,"domain_scores_codex":[0.9989895,0.00002706145,0.0002618628,0.0003532535,0.0001351047,0.0002332466],"domain_scores_gemma":[0.9987727,0.00003942447,0.0001322774,0.0005463474,0.00006105903,0.0004482314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001111839,0.0002915134,0.5681022,0.001414278,0.00006831958,0.00009557634,0.0004170604,0.0001772599,0.3929458,0.001205767,0.0001755632,0.03399486],"study_design_scores_gemma":[0.005093423,0.0001637965,0.9633148,0.0002991148,0.0001624203,0.00000159075,0.00002791788,0.002969072,0.02683004,0.0009094017,0.0000974092,0.00013107],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923079,0.005953236,0.00008178879,0.0003686802,0.00003524158,0.0007819087,0.00002588885,0.0000162641,0.0004290838],"genre_scores_gemma":[0.998537,0.0006540154,0.0001416782,0.00009007673,0.00005055388,0.00007039432,0.00007449161,0.0000157482,0.0003660114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3952126,"threshold_uncertainty_score":0.61994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783287584222453,"score_gpt":0.2851866704671512,"score_spread":0.2573537946249267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}