{"id":"W2761656877","doi":"10.1038/cddis.2017.458","title":"BCR–ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy","year":2017,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Sociedade Beneficente Israelita Brasileira Albert Einstein; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Cancer Research Society; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; University of Toronto; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Myeloid leukemia; Cancer research; Biology; K562 cells; Carcinogenesis; breakpoint cluster region; Haematopoiesis; Tyrosine kinase; Chronic myelogenous leukemia; DNA methylation; Leukemia; Immunology; Signal transduction; Cell biology; Stem cell; Cancer; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008649214,0.0001726539,0.000138987,0.000152958,0.0001321285,0.0001691033,0.00007693144,0.0001401821,0.001105197],"category_scores_gemma":[0.0000774775,0.00007310801,0.0001325018,0.0001164803,0.000153542,0.0001330643,0.0001726193,0.0003213517,0.0001950622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634868,"about_ca_system_score_gemma":0.0001266484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002208233,"about_ca_topic_score_gemma":0.0003233202,"domain_scores_codex":[0.9999475,0.000005803719,0.000004056721,0.00001451426,0.00001449665,0.00001357506],"domain_scores_gemma":[0.9999552,0.000004608825,0.00001900734,0.000004922726,0.000005872058,0.0000105086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001088556,0.00002449174,0.001488452,0.00005758171,0.00000736632,0.0001651287,0.00001936099,0.00006549176,0.9928548,0.0002290546,0.0001213222,0.004858057],"study_design_scores_gemma":[0.00005489219,0.0006071352,0.1575551,0.00003154268,0.00007399299,0.002667414,0.0001188158,0.001861915,0.8183081,0.000639918,0.01806536,0.00001584484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884393,0.005334844,0.003492779,0.0002558804,0.00004200269,0.00004106329,0.0004460322,0.0001072141,0.001840859],"genre_scores_gemma":[0.995315,0.002069108,0.0005892129,0.00007003554,0.00001256062,0.00002289313,0.0002529776,0.000006977485,0.001661175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105197,"threshold_uncertainty_score":0.003697217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783287584222453,"score_gpt":0.2851866704671512,"score_spread":0.2573537946249267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}