{"id":"W2761742990","doi":"10.1016/j.celrep.2017.09.030","title":"Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; University of Alberta; Université Laval; McGill University Health Centre; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canadian Foundation for AIDS Research; National Institutes of Health; International AIDS Society; amfAR, The Foundation for AIDS Research","keywords":"microRNA; Bystander effect; Permissiveness; Biology; Tumor necrosis factor alpha; Macrophage; Effector; Immune system; Downregulation and upregulation; Immunology; Virology; Viral replication; Virus; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627825,0.0002287347,0.0002736836,0.0001494432,0.000151647,0.0004341098,0.0001120803,0.0001993667,0.0009883209],"category_scores_gemma":[0.0001466645,0.0001626568,0.0001644007,0.00006835902,0.0001405986,0.0001240612,0.0001549199,0.0003775333,0.0004335478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167612,"about_ca_system_score_gemma":0.000208438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001444476,"about_ca_topic_score_gemma":0.00036903,"domain_scores_codex":[0.9998543,0.0000255531,0.00001114667,0.00002520336,0.0000520294,0.00003159112],"domain_scores_gemma":[0.9999375,0.00001334302,0.00001561573,0.000006929544,0.00001251867,0.00001405655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001267474,0.00003025698,0.0002230056,0.00003030348,0.000004230506,0.00001781796,0.000008853532,0.00006358782,0.9966726,0.00007001721,0.00005804658,0.00269444],"study_design_scores_gemma":[0.00001483519,0.0002523586,0.001493621,0.000003287415,0.00001392038,0.0001307747,0.00001506522,0.0008130279,0.9943466,0.00003952077,0.002874371,0.000002715483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908885,0.003175745,0.002809606,0.00009224228,0.00004936314,0.00004347139,0.0001272742,0.0001373574,0.002676426],"genre_scores_gemma":[0.9902641,0.001658436,0.004280728,0.00009774267,0.0000235614,0.00005330048,0.0002242851,0.00003317845,0.003364786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009883209,"threshold_uncertainty_score":0.003306329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006504414078705821,"score_gpt":0.2331594755424043,"score_spread":0.2266550614636984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}