{"id":"W2761745911","doi":"10.1038/s41541-017-0032-6","title":"Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines","year":2017,"lang":"en","type":"article","venue":"npj Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Vaccination; Immune system; Immunology; Antigen; Chemokine; Virology; Antibody; Messenger RNA; Innate immune system; Biology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003501387,0.000383423,0.0003144749,0.000152265,0.0001205626,0.000335738,0.0002256568,0.0003862388,0.0007846547],"category_scores_gemma":[0.0003741634,0.0001442303,0.0002019122,0.000109725,0.0004178205,0.0003179201,0.0002433117,0.0005342524,0.0005657894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881476,"about_ca_system_score_gemma":0.0002841392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001595046,"about_ca_topic_score_gemma":0.0002776543,"domain_scores_codex":[0.9996437,0.00008745944,0.00002255071,0.00007810233,0.0001290302,0.0000392047],"domain_scores_gemma":[0.9998567,0.00004507781,0.00004594541,0.00002085402,0.00001987166,0.00001149009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003355057,0.000009011655,0.00007494913,0.00005776434,0.00000288215,0.00004248278,0.00001204643,0.0001770276,0.9954017,0.000629487,0.00002810847,0.003530922],"study_design_scores_gemma":[0.0000060374,0.0003512751,0.0002493613,0.000007619946,0.00001399614,0.0001537963,0.000009344704,0.0006018491,0.9919977,0.0001833301,0.006421557,0.000004290436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8013801,0.0125584,0.1746455,0.0008316789,0.0003697392,0.0002167199,0.0003778602,0.0004281388,0.009191766],"genre_scores_gemma":[0.9373111,0.003874425,0.0519307,0.0002503324,0.0001215038,0.0001524803,0.0003457397,0.00009875948,0.005914935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007846547,"threshold_uncertainty_score":0.002624989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815446600539048,"score_gpt":0.2906129999708266,"score_spread":0.2724585339654361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}