{"id":"W2761745911","doi":"10.1038/s41541-017-0032-6","title":"Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines","year":2017,"lang":"en","type":"article","venue":"npj Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Vaccination; Immune system; Immunology; Antigen; Chemokine; Virology; Antibody; Messenger RNA; Innate immune system; Biology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009385682,0.0001837848,0.0002309818,0.0001183068,0.0001953583,0.00006427359,0.000463065,0.0002028511,0.00001659713],"category_scores_gemma":[0.0003875482,0.0001616309,0.00007779422,0.00005201984,0.00007451147,0.00001362351,0.0001586908,0.0000888593,0.00001785143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001123178,"about_ca_system_score_gemma":0.00008309037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005295625,"about_ca_topic_score_gemma":0.000493085,"domain_scores_codex":[0.9990557,0.00001559324,0.0002142757,0.0003886858,0.00005173363,0.0002740079],"domain_scores_gemma":[0.9990231,0.00001861016,0.0001497163,0.0005704655,0.0001987288,0.00003941456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007818606,0.0002081739,0.1291067,0.0001143638,0.0001165813,0.00002336746,0.00005729206,0.00002731817,0.8477236,0.005312293,0.002353138,0.01417524],"study_design_scores_gemma":[0.004050536,0.001490657,0.04654704,0.0001196463,0.00005447863,0.00005826278,0.0004373647,0.0001785178,0.9232663,0.005712092,0.01743852,0.0006465783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941617,0.0005905101,0.0002952687,0.001733519,0.0003388781,0.0004379724,0.00002531629,0.00002132662,0.002395457],"genre_scores_gemma":[0.9977486,0.0001487842,0.0005424188,0.0001297257,0.0002551578,0.000142857,0.00003754863,0.00001680166,0.0009781169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08255969,"threshold_uncertainty_score":0.6591116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815446600539048,"score_gpt":0.2906129999708266,"score_spread":0.2724585339654361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}