{"id":"W2761773602","doi":"10.1002/hep.29569","title":"A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis","year":2017,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Hôpital Saint-Luc","funders":"Medical Research Council; National Institute for Health and Care Research; Intercept Pharmaceuticals; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Obeticholic acid; Ursodeoxycholic acid; Medicine; Clinical endpoint; Internal medicine; Placebo; Gastroenterology; Tolerability; Cholestasis; Randomized controlled trial; Farnesoid X receptor; Bile acid; Adverse effect; Agonist; Pathology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194987,0.00009766137,0.0007140639,0.00008473935,0.000050615,0.000007632042,0.0001266732,0.00008146501,0.00008463235],"category_scores_gemma":[0.0001807481,0.00006724393,0.0001064895,0.00003526492,0.0002665396,0.00007892019,0.00004056086,0.0001242535,0.000006423983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002815907,"about_ca_system_score_gemma":0.0001122504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005561995,"about_ca_topic_score_gemma":0.00001578362,"domain_scores_codex":[0.9991606,0.0001650603,0.0002530108,0.0001425091,0.0001192833,0.0001595038],"domain_scores_gemma":[0.9990536,0.0000715984,0.000189123,0.0005613792,0.00006631428,0.00005797537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5108836,0.0004391422,0.4863193,0.00002669966,0.0000641708,0.000009020129,0.00007348941,1.420282e-8,0.00002130702,0.000023315,0.00003289544,0.002106961],"study_design_scores_gemma":[0.5801978,0.000481827,0.4188904,0.0000339498,0.00006505586,0.000001944072,0.000003224989,0.00001580053,0.00009050584,0.00005728738,0.0001180411,0.00004414156],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965251,0.0002161967,0.00001004822,0.0002779812,0.0001319534,0.001074128,0.00001193956,0.00001146338,0.001741198],"genre_scores_gemma":[0.9991236,0.0001862727,0.0001415844,0.0003563692,0.00003259647,0.00005394848,0.00003718596,0.00001227486,0.00005617865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06931412,"threshold_uncertainty_score":0.2742128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452180939177536,"score_gpt":0.2688745822474884,"score_spread":0.2543527728557131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}