{"id":"W2761773602","doi":"10.1002/hep.29569","title":"A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis","year":2017,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Hôpital Saint-Luc","funders":"Medical Research Council; National Institute for Health and Care Research; Intercept Pharmaceuticals; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Obeticholic acid; Ursodeoxycholic acid; Medicine; Clinical endpoint; Internal medicine; Placebo; Gastroenterology; Tolerability; Cholestasis; Randomized controlled trial; Farnesoid X receptor; Bile acid; Adverse effect; Agonist; Pathology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001726334,0.001717314,0.003894177,0.0004584265,0.0004993908,0.00101693,0.0006866559,0.001847815,0.004990297],"category_scores_gemma":[0.002272984,0.0008306548,0.001381683,0.0004306149,0.001340036,0.00108942,0.0004536826,0.002396993,0.0008935367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005386572,"about_ca_system_score_gemma":0.001372536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007866859,"about_ca_topic_score_gemma":0.001988562,"domain_scores_codex":[0.9991042,0.0005484993,0.00005900147,0.0001091191,0.00004898288,0.0001302613],"domain_scores_gemma":[0.9987624,0.0003501022,0.0002160301,0.0001095901,0.00009174033,0.0004701696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9863327,0.004420617,0.0003734074,0.0002142602,0.0003087015,0.00003984456,0.00002440297,0.000131051,0.002118208,0.00005424536,0.0002457611,0.005736828],"study_design_scores_gemma":[0.9414661,0.05694767,0.0008001796,0.00001012556,0.0001409422,0.00002014961,0.0000122962,0.0001592266,0.0001788875,0.00004706236,0.0002100603,0.000007244224],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895595,0.002559868,0.0004985671,0.0007028999,0.0007344526,0.003501517,0.0005128572,0.0001151554,0.001815144],"genre_scores_gemma":[0.9865944,0.002140273,0.001369593,0.001424517,0.0006272637,0.004439238,0.0008413536,0.00002134675,0.002541994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004990297,"threshold_uncertainty_score":0.01669425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452180939177536,"score_gpt":0.2688745822474884,"score_spread":0.2543527728557131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}