{"id":"W2761835480","doi":"10.1186/s13058-017-0900-z","title":"Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Genentech; Queen's University; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Trastuzumab; Surgical oncology; Medicine; Breast cancer; Internalization; Oncology; Internal medicine; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010387,0.0001607741,0.0001692149,0.0001133892,0.0001136759,0.0002490845,0.00009222033,0.0001505086,0.001102713],"category_scores_gemma":[0.0000932292,0.00008321807,0.000151434,0.0001137931,0.0001003158,0.00009464727,0.0001173519,0.00032425,0.0002384978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002620119,"about_ca_system_score_gemma":0.0001586908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006783068,"about_ca_topic_score_gemma":0.0008573834,"domain_scores_codex":[0.9999322,0.00001060826,0.000005747043,0.00001054244,0.00001992812,0.00002110515],"domain_scores_gemma":[0.9999425,0.00001090107,0.00001203747,0.000007373066,0.000009083586,0.00001813308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001716387,0.00003768896,0.0005243119,0.00001474702,0.000006439844,0.00002985124,0.00000844928,0.00005979224,0.9983902,0.00002736598,0.0000674784,0.0006621804],"study_design_scores_gemma":[0.00003180872,0.0005480151,0.02229154,0.000004532943,0.00002205525,0.0002993602,0.00003464007,0.001822183,0.973089,0.00002385712,0.001828826,0.000004154485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981769,0.0006618932,0.000343166,0.00003376355,0.000008534467,0.00001073192,0.0001087853,0.00001908004,0.0006370241],"genre_scores_gemma":[0.9983558,0.0002466245,0.0002131981,0.00002198948,0.000003493234,0.00001391705,0.0002107191,0.000005006987,0.0009292807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102713,"threshold_uncertainty_score":0.003688931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08054531900090665,"score_gpt":0.4435854263303194,"score_spread":0.3630401073294127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}