{"id":"W2761835480","doi":"10.1186/s13058-017-0900-z","title":"Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Genentech; Queen's University; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Trastuzumab; Surgical oncology; Medicine; Breast cancer; Internalization; Oncology; Internal medicine; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002859498,0.0003348771,0.0005699893,0.0006498786,0.0005252924,0.0003573984,0.0003677151,0.0001893618,0.0004965054],"category_scores_gemma":[0.0003346349,0.0003032535,0.00009133932,0.0006204325,0.0007764504,0.0002707601,0.0002935951,0.00109381,0.00004270991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002794818,"about_ca_system_score_gemma":0.00266113,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1120511,"about_ca_topic_score_gemma":0.02538749,"domain_scores_codex":[0.995001,0.0007320705,0.0003828426,0.001006848,0.001679471,0.001197778],"domain_scores_gemma":[0.9968845,0.0002508647,0.0001072473,0.0009872139,0.001074621,0.0006955583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.009856896,0.0006600608,0.4660313,0.0005119801,0.0001896516,0.001334182,0.002266664,0.0001948792,0.04240491,0.0001338177,0.001669424,0.4747463],"study_design_scores_gemma":[0.004387194,0.0008566798,0.9676017,0.002357834,0.00001356511,0.0006137594,0.0002542454,0.002944581,0.01948737,0.0001157278,0.001004983,0.000362374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963145,0.0005182375,0.0001750814,0.0310942,0.0001697262,0.002807021,0.0005888962,0.00005827015,0.001443546],"genre_scores_gemma":[0.9969706,0.0006204316,0.0001088805,0.00045911,0.0005716946,0.000676695,0.00002442472,0.000096157,0.0004719997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5015704,"threshold_uncertainty_score":0.9999419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08054531900090665,"score_gpt":0.4435854263303194,"score_spread":0.3630401073294127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}