{"id":"W2761872853","doi":"10.1038/nrd.2017.179","title":"WD40 repeat domain proteins: a novel target class?","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; Princess Margaret Cancer Centre; Canada Research Chairs; University of Toronto","funders":"National Institutes of Health; Wellcome Trust; Ontario Genomics Institute; Genome Canada","keywords":"Druggability; Computational biology; Drug discovery; Proteome; Drug development; Protein–protein interaction; Biology; Protein domain; Human proteome project; Drug target; Architecture domain; Plasma protein binding; Small molecule; Cell biology; Bioinformatics; Drug; Genetics; Biochemistry; Proteomics; Pharmacology; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000686335,0.000858989,0.001957381,0.001208557,0.0001890913,0.00149372,0.001163584,0.001337991,0.003629978],"category_scores_gemma":[0.0006610038,0.0002843458,0.0005122921,0.001100894,0.0006804408,0.001872656,0.0008901097,0.002759324,0.002794222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005097489,"about_ca_system_score_gemma":0.0007599997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004216388,"about_ca_topic_score_gemma":0.00125091,"domain_scores_codex":[0.9997885,0.00002829604,0.00002939408,0.00003421872,0.00008801887,0.00003147342],"domain_scores_gemma":[0.9997178,0.0001151798,0.00004982038,0.000009393138,0.00006931032,0.00003846316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001533893,0.00005806735,0.0002613874,0.006341837,0.0001308789,0.0003433357,0.0000273947,0.0001903879,0.002911315,0.004608369,0.04624913,0.9387246],"study_design_scores_gemma":[0.00005296347,0.0001054896,0.0004171895,0.001276901,0.0001502071,0.001795389,0.0000381287,0.0001410565,0.0007553177,0.002507835,0.9927406,0.00001900654],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002019218,0.9970188,0.000374758,0.000944649,0.0003713404,0.00000406563,0.00003106364,0.00001668179,0.001036835],"genre_scores_gemma":[0.001293875,0.9960648,0.000330925,0.0008379997,0.0004316418,0.000006736102,0.00006414655,0.00000303885,0.0009667978],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003629978,"threshold_uncertainty_score":0.01214349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06426096705800248,"score_gpt":0.3931042872845099,"score_spread":0.3288433202265074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}