{"id":"W2761902517","doi":"10.1093/annonc/mdx370.051","title":"Randomized phase III trial of ipatasertib vs. placebo, plus abiraterone and prednisone/prednisolone, in men with asymptomatic or mildly symptomatic previously untreated metastatic castrate-resistant prostate cancer (mCRPC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Prednisone; Internal medicine; Prednisolone; Prostate cancer; Population; Oncology; Placebo; Clinical endpoint; Abiraterone acetate; Androgen deprivation therapy; Gastroenterology; Cancer; Randomized controlled trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001672232,0.002591476,0.003580954,0.0005064165,0.0006377939,0.001753675,0.001364976,0.002004391,0.01134153],"category_scores_gemma":[0.001990189,0.001038788,0.002596626,0.0005850114,0.001807997,0.001433573,0.0006312095,0.005672121,0.002298973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001088796,"about_ca_system_score_gemma":0.001631098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002254619,"about_ca_topic_score_gemma":0.005796197,"domain_scores_codex":[0.9994318,0.000273664,0.00003200865,0.0001196837,0.00003754401,0.0001052141],"domain_scores_gemma":[0.9989693,0.0002582317,0.000214654,0.00009158056,0.00005589074,0.0004102833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9877449,0.002286772,0.0001615003,0.000300767,0.0006301706,0.00002231231,0.00002721808,0.0002227966,0.0009195386,0.0001069395,0.0007175871,0.006859493],"study_design_scores_gemma":[0.9830667,0.01552265,0.0004107506,0.00001637813,0.0002605614,0.00001861994,0.00001554034,0.0001361667,0.00009110365,0.0001297645,0.0003249307,0.000007001436],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605752,0.01043115,0.001852026,0.003111027,0.003818568,0.006590927,0.004052184,0.0005824062,0.008986616],"genre_scores_gemma":[0.9708121,0.00456135,0.002625781,0.003232313,0.00134464,0.00487337,0.002828289,0.0000756222,0.009646453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01134153,"threshold_uncertainty_score":0.03794122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08097807817073079,"score_gpt":0.422389176494606,"score_spread":0.3414110983238752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}