{"id":"W2761908654","doi":"10.1007/164_2017_63","title":"Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells","year":2017,"lang":"en","type":"review","venue":"Handbook of experimental pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Node of Ranvier; Biophysics; Neuroscience; CLs upper limits; Chemistry; Membrane potential; Medicine; Biology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676629,0.0002784133,0.0007977568,0.0000960506,0.0001108436,0.00001010874,0.0003223131,0.0003253987,0.0001336987],"category_scores_gemma":[0.00002407141,0.0002118258,0.0002832385,0.0000536628,0.0005236079,0.00000894784,0.0001801283,0.0001783289,0.00000474669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004482061,"about_ca_system_score_gemma":0.0001798313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008453081,"about_ca_topic_score_gemma":0.000006893143,"domain_scores_codex":[0.998517,0.0002904837,0.0004744446,0.0003513618,0.0001265045,0.0002401871],"domain_scores_gemma":[0.9988333,0.00006659968,0.0007248687,0.0002729027,0.00005464155,0.00004766741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001452547,0.000205707,0.000004338614,0.000921538,0.0001902927,0.000004445979,0.000167892,0.00004184278,0.9799119,0.00001317221,0.0008129083,0.01758066],"study_design_scores_gemma":[0.0005741637,0.0001911222,0.000001937729,0.0006922971,0.00008065581,0.00001497434,0.00006484098,0.00007512607,0.8403995,0.000006285022,0.1577193,0.0001797885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007169925,0.9898527,0.00007130791,0.00001395837,0.001470149,0.0007757189,0.0000468058,0.000005785548,0.0005936924],"genre_scores_gemma":[0.1397679,0.8588813,0.0000394991,0.00004396267,0.0004481554,0.0001097759,0.0001054314,0.00003312444,0.0005708771],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1569064,"threshold_uncertainty_score":0.8638007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0868971644950499,"score_gpt":0.3927385098087366,"score_spread":0.3058413453136867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}