{"id":"W2761916823","doi":"10.1002/art.40133","title":"Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms","year":2017,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"NIHR Newcastle Biomedical Research Centre; Medical Research Council; National Cancer Institute; National Institutes of Health; Versus Arthritis; U.S. Department of Defense; JGW Patterson Foundation; Arthritis Research UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Nuffield Foundation","keywords":"Aggrecan; Aggrecanase; Cartilage; Chemistry; Metalloproteinase; Matrix metalloproteinase; ADAMTS; Osteoarthritis; Cell biology; Type II collagen; Extracellular matrix; Molecular biology; Thrombospondin; Biochemistry; Pathology; Medicine; Biology; Anatomy; Articular cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004681286,0.0007446738,0.0005715687,0.000315901,0.0001433986,0.0003568565,0.0001832741,0.0002689381,0.001254495],"category_scores_gemma":[0.000182877,0.000183463,0.0005802681,0.0001727214,0.0002441478,0.0002726221,0.000195172,0.0004837432,0.0004057627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679867,"about_ca_system_score_gemma":0.0002677099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003837402,"about_ca_topic_score_gemma":0.0005701382,"domain_scores_codex":[0.9996924,0.00006523411,0.00004363086,0.00004794033,0.0000828902,0.00006779006],"domain_scores_gemma":[0.99978,0.00003726247,0.0000715257,0.00002665026,0.00002905072,0.00005549117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816577,0.00003333819,0.00008384539,0.00006032013,0.000006350811,0.00002924079,0.00000813001,0.00001584193,0.9990082,0.00001343058,0.00001238417,0.0005473311],"study_design_scores_gemma":[0.00002340454,0.000877778,0.002068815,0.000005154336,0.00002252541,0.0001841114,0.00001180084,0.0003035924,0.9958357,0.000009931736,0.0006545523,0.000002666631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797537,0.01128581,0.006854343,0.0001282748,0.00008244972,0.0001138673,0.0004384857,0.0001191682,0.001223953],"genre_scores_gemma":[0.9899873,0.002982622,0.00387144,0.00005095215,0.00005390064,0.00009917958,0.0005260452,0.00001481346,0.002413705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254495,"threshold_uncertainty_score":0.004196703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057217494106388,"score_gpt":0.2391288352276492,"score_spread":0.2285566602865853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}