{"id":"W2761940121","doi":"10.1038/nnano.2017.188","title":"A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis","year":2017,"lang":"en","type":"article","venue":"Nature Nanotechnology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Wellcome Trust","keywords":"G protein-coupled receptor; Endocytosis; Clathrin; Internalization; Allosteric regulation; Cell biology; Scaffold protein; Chemistry; Biology; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102077,0.0004311835,0.0003387926,0.0002355049,0.0002407939,0.0004442154,0.0006291934,0.0006299189,0.001443439],"category_scores_gemma":[0.0001564429,0.000193347,0.0002774257,0.0001324964,0.0003034576,0.0003614188,0.0003335016,0.0008831393,0.0006437466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006048474,"about_ca_system_score_gemma":0.0003632345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003949049,"about_ca_topic_score_gemma":0.0006777453,"domain_scores_codex":[0.9997973,0.00002118892,0.00001037002,0.00005730072,0.00005540731,0.0000584111],"domain_scores_gemma":[0.9999275,0.00001410257,0.00001740364,0.00001148008,0.000008873463,0.00002068901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000538169,0.0000197087,0.0000246032,0.00004382574,0.000004827551,0.00004162274,0.000009590583,0.0000977444,0.9973073,0.0005410379,0.0001372992,0.001718539],"study_design_scores_gemma":[0.00001531798,0.0001256903,0.0001528791,0.000003082133,0.000009107403,0.000184054,0.000004216857,0.0005685582,0.9946163,0.00004361347,0.004272695,0.000004433915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8674771,0.007995985,0.09695296,0.001026018,0.0003459928,0.0003472861,0.001202495,0.001375193,0.02327707],"genre_scores_gemma":[0.9627507,0.002380342,0.02214512,0.0004044427,0.00003639978,0.0001248004,0.0008958392,0.0001296027,0.01113274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443439,"threshold_uncertainty_score":0.004828811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00531468419248805,"score_gpt":0.236194003380188,"score_spread":0.2308793191876999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}