{"id":"W2761940121","doi":"10.1038/nnano.2017.188","title":"A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis","year":2017,"lang":"en","type":"article","venue":"Nature Nanotechnology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Wellcome Trust","keywords":"G protein-coupled receptor; Endocytosis; Clathrin; Internalization; Allosteric regulation; Cell biology; Scaffold protein; Chemistry; Biology; Receptor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233236,0.0001560615,0.0002315787,0.00009643151,0.0001697142,0.00001960094,0.0003225905,0.001053416,0.00001465852],"category_scores_gemma":[0.0003842762,0.0001411187,0.00006994024,0.0000614185,0.0002407032,0.000003613614,0.0001452982,0.0003460819,0.000001256922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001175108,"about_ca_system_score_gemma":0.00007375837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001456608,"about_ca_topic_score_gemma":0.00002175464,"domain_scores_codex":[0.9991079,0.00002935672,0.0001590187,0.0003888005,0.00009405506,0.0002208568],"domain_scores_gemma":[0.9991019,0.00001485097,0.0001942186,0.0005433232,0.0001061954,0.0000395465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006719158,0.00002998258,0.0003130479,0.00001728479,0.00003620055,0.000003452389,0.000008485123,0.000006234,0.9870099,0.0009247269,0.0001318476,0.01145168],"study_design_scores_gemma":[0.0005292256,0.0003888511,0.0001633631,0.00002175674,0.00002322723,0.00002048169,0.00001523262,0.00009485987,0.9934817,0.001111245,0.004002488,0.000147568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945923,0.002483409,0.001802611,0.0005152599,0.000239365,0.0001617724,0.00001689672,0.0000252117,0.0001631626],"genre_scores_gemma":[0.9959168,0.000181322,0.003589938,0.0001318335,0.0001011302,0.00002123112,0.00001003257,0.00002063507,0.00002704727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01130411,"threshold_uncertainty_score":0.8124906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00531468419248805,"score_gpt":0.236194003380188,"score_spread":0.2308793191876999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}