{"id":"W2762008010","doi":"10.1186/s12944-017-0591-6","title":"Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos","year":2017,"lang":"en","type":"article","venue":"Lipids in Health and Disease","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; Banting and Best Diabetes Centre, University of Toronto; Instituto Mexicano del Seguro Social; Canadian Institutes of Health Research; American Heart Association; University of Washington; National Heart, Lung, and Blood Institute; University of Miami; Northwestern University; Wake Forest School of Medicine; National Institute on Deafness and Other Communication Disorders; Texas Health and Human Services Commission; San Diego State University; National Institutes of Health; U.S. Department of Health and Human Services; Office of Dietary Supplements; National Institute of Diabetes and Digestive and Kidney Diseases; Fundación IMSS; Women's Health Initiative; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; University of Texas Health Science Center at Houston; Consejo Nacional de Ciencia y Tecnología","keywords":"Genome-wide association study; Genetic architecture; Single-nucleotide polymorphism; Biology; SNP; Genetic association; Genetics; Heritability; Trait; Minor allele frequency; Quantitative trait locus; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001801839,0.0002806053,0.0002969005,0.0009935446,0.0006403606,0.0005828575,0.0003245652,0.0002498085,0.001167209],"category_scores_gemma":[0.002649432,0.0001876245,0.0003702604,0.001327947,0.000471612,0.0001732366,0.0006583124,0.0003451364,0.0001015168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002706383,"about_ca_system_score_gemma":0.0005258041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01677716,"about_ca_topic_score_gemma":0.01560266,"domain_scores_codex":[0.9990425,0.0004861202,0.00006460989,0.0002362552,0.00009279049,0.00007773473],"domain_scores_gemma":[0.9990244,0.0001915214,0.0003347246,0.0001821213,0.000115435,0.0001517963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000234865,0.00003637087,0.9963524,0.00000879945,0.000209486,0.0001253626,0.0002035392,0.00008132758,0.0008900816,0.0001936586,0.0001429753,0.001520972],"study_design_scores_gemma":[0.00003252846,0.00003494253,0.9981609,0.00001363544,0.0001178022,0.0001665631,0.0003853526,0.0004672308,0.0001190554,0.0002816694,0.0002151894,0.000005112145],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982576,0.0002701585,0.0003429787,0.00011093,0.000007471096,0.00001690969,0.000270903,0.000007977932,0.000714979],"genre_scores_gemma":[0.9993291,0.0001125637,0.000197264,0.00004020214,0.000007812828,0.00001707877,0.0001873113,0.000006991669,0.0001017009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01677716,"threshold_uncertainty_score":0.03335899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03067688199670156,"score_gpt":0.3382086370631191,"score_spread":0.3075317550664176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}