{"id":"W2762054879","doi":"10.1172/jci96036","title":"mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania; National Institutes of Health; American Diabetes Association","keywords":"mTORC1; Secretion; Postprandial; Biochemistry; Lipid metabolism; Internal medicine; Very low-density lipoprotein; Chemistry; Endocrinology; Biology; PI3K/AKT/mTOR pathway; Lipoprotein; Signal transduction; Cholesterol; Medicine; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002128204,0.0005385507,0.0004558809,0.0006204927,0.00021841,0.0005572785,0.0002367429,0.0003930141,0.002195073],"category_scores_gemma":[0.0002618993,0.0002356871,0.0004074628,0.0002775021,0.0002551886,0.0002477036,0.0004506037,0.001009269,0.001009755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004887012,"about_ca_system_score_gemma":0.0005047197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005412377,"about_ca_topic_score_gemma":0.001031193,"domain_scores_codex":[0.9997992,0.000032206,0.00001983821,0.00004411452,0.00005027228,0.000054451],"domain_scores_gemma":[0.9999133,0.0000104459,0.00002345783,0.000007653791,0.00001800284,0.00002708233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001128061,0.0002213898,0.0006098392,0.000552648,0.00004995979,0.0001492382,0.00003267921,0.0003986891,0.9746967,0.001014344,0.002306728,0.01883973],"study_design_scores_gemma":[0.0002926564,0.001324378,0.01098962,0.0000676831,0.0001131638,0.0005693972,0.00005159194,0.003706563,0.9529424,0.0004801999,0.02943387,0.00002853093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9215205,0.03875083,0.01102018,0.003038166,0.001126896,0.0003408138,0.002875396,0.001739531,0.01958772],"genre_scores_gemma":[0.9766947,0.01007628,0.004369441,0.0004699022,0.0002541372,0.0001918504,0.001496014,0.00008750325,0.006360142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002195073,"threshold_uncertainty_score":0.007343233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05349823584442829,"score_gpt":0.3656280386875698,"score_spread":0.3121298028431415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}