{"id":"W2762084864","doi":"10.1093/annonc/mdx365.052","title":"The CAN BEAR study: A systematic review and meta-analysis investigating adverse events (AEs) of targeted agents added to endocrine therapy (ET) in patients (pts) with hormone-receptor positive (HR+) metastatic breast cancer (MBC)","year":2017,"lang":"en","type":"review","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Charles-Le Moyne","funders":"","keywords":"Medicine; Internal medicine; Meta-analysis; Oncology; Adverse effect; Odds ratio; Cochrane Library; Confidence interval; Randomized controlled trial; Targeted therapy; Metastatic breast cancer; Breast cancer; Pharmacology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.005793524,0.001829461,0.01228006,0.002498525,0.0004129429,0.002016649,0.001459364,0.001627173,0.005847659],"category_scores_gemma":[0.01839515,0.0008906937,0.01881,0.003324202,0.0004754651,0.001374985,0.001430694,0.001958891,0.0004272851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001706521,"about_ca_system_score_gemma":0.002278093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005620594,"about_ca_topic_score_gemma":0.02110294,"domain_scores_codex":[0.9960639,0.001785544,0.001127115,0.0004142855,0.0004466113,0.0001626339],"domain_scores_gemma":[0.9942854,0.003773435,0.001181309,0.0002536368,0.0003864443,0.0001199076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004931736,0.000053655,0.00243443,0.4921229,0.4814558,0.0001652344,0.0001208122,0.0002483309,0.0004191913,0.000201331,0.001349026,0.01649759],"study_design_scores_gemma":[0.002496648,0.0003549154,0.003546789,0.02362179,0.9656633,0.0001122937,0.00006241024,0.00007486787,0.00009684576,0.0001902139,0.003750607,0.0000292971],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00672691,0.9908412,0.0003824784,0.0002606449,0.0002327905,0.0003936511,0.0007258715,0.0000251837,0.0004112464],"genre_scores_gemma":[0.1824001,0.8090242,0.002603979,0.002383902,0.0003175802,0.001179627,0.001002368,0.00003230442,0.001055991],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.98772,"threshold_uncertainty_score":0.03063947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.19634231387763,"score_gpt":0.4687768820763335,"score_spread":0.2724345681987035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}