{"id":"W2762098071","doi":"10.1093/annonc/mdx365.086","title":"EarLEE-1: A phase 3 study of ribociclib + endocrine therapy (ET) for adjuvant treatment of patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), high-risk, early breast cancer (EBC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Letrozole; Internal medicine; Breast cancer; Oncology; Exemestane; Anastrozole; Placebo; Tamoxifen; Docetaxel; Gastroenterology; Cancer; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001213012,0.001216776,0.001397983,0.000351315,0.0003343681,0.0008911717,0.0009538252,0.001017639,0.006009717],"category_scores_gemma":[0.0007169788,0.0004166688,0.001306887,0.0003759861,0.0005534075,0.0007411244,0.0003310649,0.002727658,0.001022768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000809573,"about_ca_system_score_gemma":0.001469044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002317536,"about_ca_topic_score_gemma":0.00992356,"domain_scores_codex":[0.9997599,0.0000952253,0.00001063641,0.00003702083,0.0000234216,0.00007381079],"domain_scores_gemma":[0.9996645,0.00006383553,0.00004594219,0.00002643819,0.00001925962,0.0001798972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6263802,0.06740724,0.00743538,0.001494876,0.002293234,0.0002660249,0.000376654,0.005917646,0.05243572,0.0007891662,0.01050553,0.2246984],"study_design_scores_gemma":[0.6156702,0.3519225,0.01383719,0.00008331524,0.001059475,0.0004563016,0.0001265092,0.002028859,0.00537944,0.0004396248,0.008942762,0.00005379114],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825226,0.003992377,0.0009758683,0.0008131267,0.0002362642,0.002874706,0.002985108,0.0002876223,0.00531235],"genre_scores_gemma":[0.9632425,0.005821823,0.004810299,0.002669626,0.0002148607,0.003516512,0.008329027,0.0001268456,0.01126847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006009717,"threshold_uncertainty_score":0.02010453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0632172734733662,"score_gpt":0.4072447844141872,"score_spread":0.344027510940821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}