{"id":"W2762098071","doi":"10.1093/annonc/mdx365.086","title":"EarLEE-1: A phase 3 study of ribociclib + endocrine therapy (ET) for adjuvant treatment of patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), high-risk, early breast cancer (EBC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Letrozole; Internal medicine; Breast cancer; Oncology; Exemestane; Anastrozole; Placebo; Tamoxifen; Docetaxel; Gastroenterology; Cancer; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000193838,0.0004910071,0.001822895,0.0001933682,0.0002456249,0.00001127777,0.0003005726,0.0001396251,0.0002214089],"category_scores_gemma":[0.0001091209,0.0003555594,0.0002445547,0.0001331931,0.000669278,0.0003543147,0.00006460523,0.0002035,0.00000230449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661141,"about_ca_system_score_gemma":0.0003179444,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01640516,"about_ca_topic_score_gemma":0.0009650771,"domain_scores_codex":[0.9972201,0.0003369376,0.0008703409,0.0005986465,0.0004332202,0.0005407606],"domain_scores_gemma":[0.9945431,0.000427737,0.002263978,0.0006823313,0.001871665,0.000211158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.08846752,0.03398091,0.2790337,0.0001007901,0.005631555,0.00002598277,0.02070285,0.00001012403,0.02492406,0.00009075206,0.0002917296,0.5467401],"study_design_scores_gemma":[0.06214289,0.1314338,0.7214333,0.0001118196,0.0002561624,0.00000544346,0.0008704184,0.000002148104,0.08268289,0.0001157004,0.0006892674,0.0002561517],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901881,0.0005555224,0.00005581679,0.001465251,0.0001478269,0.003402038,0.004075063,0.00002777294,0.00008264497],"genre_scores_gemma":[0.9960395,0.001680211,0.0009221195,0.0001358215,0.0001976164,0.0006973954,0.0001146287,0.00008576128,0.0001269753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5464839,"threshold_uncertainty_score":0.9998896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0632172734733662,"score_gpt":0.4072447844141872,"score_spread":0.344027510940821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}