{"id":"W2762200378","doi":"10.1038/nmat4994","title":"Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease","year":2017,"lang":"en","type":"article","venue":"Nature Materials","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":298,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Center for Advancing Translational Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Polycystic kidney disease; Organoid; Induced pluripotent stem cell; Cyclic adenosine monophosphate; Cell biology; Stromal cell; Biology; Kidney; Cancer research; Embryonic stem cell; Endocrinology; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488184,0.000180218,0.0002536443,0.00004083011,0.0001304474,0.00005216715,0.0003877109,0.0002497883,0.0002900131],"category_scores_gemma":[0.000946837,0.0001699803,0.00007257914,0.00001759351,0.0001838062,0.000004441516,0.0002259411,0.00006173592,0.00001092046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001382478,"about_ca_system_score_gemma":0.00008806465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002758763,"about_ca_topic_score_gemma":0.000002662965,"domain_scores_codex":[0.9988478,0.00008713076,0.0002924925,0.0003616994,0.0001503119,0.0002605485],"domain_scores_gemma":[0.9987536,0.000007447265,0.0001312556,0.0007698082,0.00003380287,0.0003040635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002672877,0.0001360473,0.006700116,0.0001129139,0.00001917059,0.0000137647,0.00001047754,6.302658e-7,0.9913566,0.00008984104,0.001261549,0.00003159193],"study_design_scores_gemma":[0.0004233172,0.00006028366,0.177786,0.00006736538,0.00004700043,0.000003284882,0.00001267459,2.210958e-7,0.8189718,0.0006025771,0.00186886,0.0001565955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962105,0.002002035,0.000007635291,0.0003779467,0.0002355013,0.00020527,0.00069541,0.000005489987,0.0002601982],"genre_scores_gemma":[0.998551,0.00006661738,0.0002174762,0.0004603665,0.0002370987,0.00003101839,0.0002095226,0.00002788381,0.0001990542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1723848,"threshold_uncertainty_score":0.6931596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004113999761342064,"score_gpt":0.2602260871175883,"score_spread":0.2561120873562462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}