{"id":"W2762202707","doi":"10.1101/198234","title":"Genetic analysis of over one million people identifies 535 novel loci for blood pressure","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Barts and The London School of Medicine and Dentistry; Medical Research Council; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; National Institutes of Health; UK Dementia Research Institute; China Scholarship Council; Public Health England; ZonMw; National Medical Research Council; King's College London; Wellcome Trust; Cancer Research UK; Imperial College Healthcare NHS Trust; Netherlands Heart Institute; GlaxoSmithKline; Imperial College London; Novo Nordisk Fonden; Cisco Systems; Agence Nationale de la Recherche; Ministero della Salute; Alzheimer's Society; British Heart Foundation; Brigham and Women's Hospital; Université Laval; Novo Nordisk; National Institute on Aging; National Institute for Health and Care Research; British Lung Foundation; National Institute for Health Research Health Protection Research Unit; EU Joint Programme – Neurodegenerative Disease Research; U.S. Department of Veterans Affairs","keywords":"Blood pressure; Pulse pressure; Disease; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007885191,0.0004039963,0.0004857664,0.0008229183,0.000579581,0.0007094875,0.0003275275,0.0007310953,0.004029191],"category_scores_gemma":[0.002541022,0.0002607947,0.0008799051,0.002080233,0.000337806,0.0001771394,0.0005794858,0.0005429126,0.0006646499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064471,"about_ca_system_score_gemma":0.0002730385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003509804,"about_ca_topic_score_gemma":0.003215425,"domain_scores_codex":[0.9992612,0.000156561,0.00005573385,0.0002752585,0.0001593454,0.00009187643],"domain_scores_gemma":[0.9988055,0.0003590917,0.0003809067,0.0001977759,0.00009984367,0.0001568675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008891217,0.0001020466,0.9381198,0.0001248756,0.001543173,0.001364137,0.0004836172,0.0005575708,0.02212155,0.0006263588,0.004007889,0.03006001],"study_design_scores_gemma":[0.00006033407,0.00008573214,0.9924421,0.00003052998,0.0003677052,0.001003337,0.0001136092,0.0004852945,0.001863057,0.0007264219,0.002806439,0.00001558604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990671,0.00113507,0.002197943,0.0004358725,0.00004139114,0.00001484647,0.004430448,0.00006594641,0.001007494],"genre_scores_gemma":[0.9946736,0.0004684551,0.001815331,0.0001939068,0.00005560266,0.00002065124,0.001990949,0.00002305502,0.0007584625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004029191,"threshold_uncertainty_score":0.01347899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590162095756583,"score_gpt":0.2478888889156957,"score_spread":0.2319872679581299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}