{"id":"W2762417051","doi":"10.1016/j.ijpddr.2017.10.004","title":"Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani","year":2017,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Indian Council of Medical Research; Faculté de Médecine, Université Laval; Université Laval","keywords":"Paromomycin; Leishmania donovani; Biology; Transcriptome; Microbiology; Miltefosine; Gene; Visceral leishmaniasis; Leishmaniasis; Gene expression; Genetics; Antibiotics; Aminoglycoside","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007767783,0.0002576598,0.0005405989,0.0002984745,0.0007108891,0.0003547693,0.0005464731,0.00008972919,0.00001268233],"category_scores_gemma":[0.0005405231,0.0002170936,0.0001157397,0.00008501073,0.0003082019,0.0004068833,0.00008923373,0.0003571296,0.000004632024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003507962,"about_ca_system_score_gemma":0.000160203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003109879,"about_ca_topic_score_gemma":0.002709752,"domain_scores_codex":[0.9977267,0.00008307618,0.0005369966,0.0004861829,0.0006629038,0.0005041881],"domain_scores_gemma":[0.9982935,0.000210046,0.000355025,0.0002945512,0.0006285429,0.0002183902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02904809,0.001637667,0.7476603,0.0002783693,0.002694536,0.004861147,0.0133513,0.00004033873,0.1569266,0.01912867,0.02169904,0.00267391],"study_design_scores_gemma":[0.02026624,0.0006019332,0.7620621,0.003225818,0.0001676556,0.0005495923,0.007734681,0.00008092518,0.1624551,0.004385734,0.03733554,0.001134686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825383,0.003337888,0.0002091917,0.01031248,0.0007583121,0.0006309536,0.00005154046,0.00002692994,0.00213436],"genre_scores_gemma":[0.9907296,0.0003730549,0.001998412,0.0002352131,0.0002525434,0.0001590815,0.00001525042,0.00003411323,0.006202763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0156365,"threshold_uncertainty_score":0.885282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204117717002988,"score_gpt":0.3651960733929264,"score_spread":0.3331548962228965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}