{"id":"W2762440037","doi":"10.1093/annonc/mdx393.049","title":"Mechanism of pelareorep (Pel)-mediated cell death in a Phase I study in combination with irinotecan/fluorouracil/leucovorin/bevacizumab (FOLFIRI/B) in patients with KRAS mutant metastatic colorectal cancer (mCRC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"FOLFIRI; Medicine; Irinotecan; KRAS; Bevacizumab; Oxaliplatin; Neutropenia; Internal medicine; Colorectal cancer; Fluorouracil; Cancer research; Toxicity; Gastroenterology; Oncology; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007691244,0.000791919,0.001301725,0.0003955582,0.0002956257,0.0008270639,0.0007983232,0.0008449281,0.00336042],"category_scores_gemma":[0.0003421846,0.0005004157,0.001145599,0.0003601169,0.0006308231,0.0008560063,0.0002608971,0.002450811,0.0005392737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005632379,"about_ca_system_score_gemma":0.0008128238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005760427,"about_ca_topic_score_gemma":0.001805845,"domain_scores_codex":[0.9997471,0.0001040257,0.0000125528,0.00004242559,0.00002229878,0.00007168292],"domain_scores_gemma":[0.9998466,0.00003315033,0.00002807653,0.00001803305,0.000009499396,0.0000645539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4291107,0.07186575,0.005795624,0.002008476,0.002302141,0.0005291257,0.0004942918,0.006126015,0.2025076,0.001047735,0.003119409,0.2750932],"study_design_scores_gemma":[0.2154524,0.7357976,0.01080692,0.00007012102,0.001267627,0.0007724019,0.000142894,0.002275368,0.02798736,0.0002779947,0.00509974,0.00004959514],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927827,0.003965756,0.0005310012,0.0002560118,0.00006848504,0.0006791011,0.0002904997,0.00007199436,0.001354427],"genre_scores_gemma":[0.9949006,0.002283343,0.0006982714,0.0002126064,0.00005091369,0.0004605294,0.0004224604,0.00001348726,0.0009577586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00336042,"threshold_uncertainty_score":0.01124173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03956383169501896,"score_gpt":0.3713207052363089,"score_spread":0.33175687354129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}