{"id":"W2762449338","doi":"10.3389/fendo.2017.00253","title":"Culture in Glucose-Depleted Medium Supplemented with Fatty Acid and 3,3′,5-Triiodo-l-Thyronine Facilitates Purification and Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes","year":2017,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; School of Medicine, New York University; National Institutes of Health; National Natural Science Foundation of China; Independent Order of Odd Fellows; York University; New York Academy of Medicine; National Institute of General Medical Sciences; American Heart Association","keywords":"Induced pluripotent stem cell; Myocyte; Repolarization; Cell biology; Stem cell; Fatty acid; Thyronine; Biology; Biochemistry; Chemistry; Cell culture; Internal medicine; Electrophysiology; Embryonic stem cell; Triiodothyronine; Hormone; Gene; Medicine; Genetics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441478,0.0002045501,0.0003457574,0.0001751996,0.0001366353,0.00003473784,0.0002706953,0.0001582766,0.000002781872],"category_scores_gemma":[0.00003186709,0.0001794433,0.00003118127,0.00006055874,0.0004352342,0.00002186048,0.0002083748,0.0001884932,4.598647e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000411824,"about_ca_system_score_gemma":0.00003786159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000130306,"about_ca_topic_score_gemma":0.0002592449,"domain_scores_codex":[0.9984701,0.0001518575,0.0003160033,0.0005054664,0.0001595837,0.0003970209],"domain_scores_gemma":[0.9991882,0.000008354596,0.0001890682,0.000461696,0.00008710887,0.00006559815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003883046,0.00004957826,0.1138373,0.00009727944,0.00005783634,0.00002133521,0.000285488,0.00001311407,0.8838177,0.00001429639,0.0003186662,0.001099115],"study_design_scores_gemma":[0.002755386,0.0004471591,0.1581121,0.00002340645,0.00001717515,0.0000227465,0.00114229,0.0001065281,0.8360525,0.00004079395,0.001106324,0.0001735161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924016,0.005267646,0.001113722,0.0003767521,0.00009783254,0.0005452378,0.00006344818,0.00000999554,0.0001237701],"genre_scores_gemma":[0.9949353,0.002215526,0.002313065,0.00001220684,0.00002783958,0.00007557445,0.0002710496,0.00001790024,0.0001315865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04776509,"threshold_uncertainty_score":0.7317485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133361293965274,"score_gpt":0.2485512902678527,"score_spread":0.2372176773282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}