{"id":"W2762449338","doi":"10.3389/fendo.2017.00253","title":"Culture in Glucose-Depleted Medium Supplemented with Fatty Acid and 3,3′,5-Triiodo-l-Thyronine Facilitates Purification and Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes","year":2017,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; School of Medicine, New York University; National Institutes of Health; National Natural Science Foundation of China; Independent Order of Odd Fellows; York University; New York Academy of Medicine; National Institute of General Medical Sciences; American Heart Association","keywords":"Induced pluripotent stem cell; Myocyte; Repolarization; Cell biology; Stem cell; Fatty acid; Thyronine; Biology; Biochemistry; Chemistry; Cell culture; Internal medicine; Electrophysiology; Embryonic stem cell; Triiodothyronine; Hormone; Gene; Medicine; Genetics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590087,0.0003873051,0.0003280349,0.0002328715,0.0001749107,0.0003225887,0.0002568693,0.0002129946,0.001026352],"category_scores_gemma":[0.00009926484,0.00009912172,0.0002440135,0.0002544059,0.0001816625,0.0001827421,0.0002639322,0.0004703162,0.0004022737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608823,"about_ca_system_score_gemma":0.0002917103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000506905,"about_ca_topic_score_gemma":0.001080026,"domain_scores_codex":[0.9997986,0.00002112644,0.0000311346,0.00005735602,0.00006519476,0.00002664465],"domain_scores_gemma":[0.9999069,0.00001773843,0.00002506085,0.00001149511,0.00001620579,0.00002258558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005042713,0.00000803588,0.0001139177,0.00003152686,0.000002357087,0.00005707667,0.00001463326,0.00002526145,0.9988813,0.00003218374,0.00002348719,0.0007597652],"study_design_scores_gemma":[0.00001106446,0.0001786949,0.002601018,0.00001135193,0.00001900434,0.000272524,0.00002329464,0.0005424393,0.9928074,0.00004112319,0.003485151,0.00000690992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463634,0.006351837,0.03942042,0.0002423478,0.0001375365,0.0001685042,0.002062948,0.0003363545,0.004916683],"genre_scores_gemma":[0.9442627,0.004646828,0.0360632,0.0002565631,0.00005242017,0.0003315734,0.005515036,0.000132304,0.00873927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026352,"threshold_uncertainty_score":0.003433526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133361293965274,"score_gpt":0.2485512902678527,"score_spread":0.2372176773282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}