{"id":"W2762460943","doi":"10.1213/ane.0000000000002469","title":"Intraoperative Esmolol as an Adjunct for Perioperative Opioid and Postoperative Pain Reduction: A Systematic Review, Meta-analysis, and Meta-regression","year":2017,"lang":"en","type":"review","venue":"Anesthesia & Analgesia","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Medicine; Esmolol; Anesthesia; Opioid; Perioperative; Meta-analysis; Placebo; Randomized controlled trial; Confidence interval; Surgery; Internal medicine; Heart rate; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003597968,0.001845294,0.01964119,0.0006310975,0.0009827127,0.0003413367,0.0004861449,0.0006223553,0.000439134],"category_scores_gemma":[0.0007441136,0.000950628,0.004463869,0.0006104266,0.0005665565,0.0005907067,0.00006822722,0.0006539865,0.00003197541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251737,"about_ca_system_score_gemma":0.0005836151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001635551,"about_ca_topic_score_gemma":0.00002784277,"domain_scores_codex":[0.9907907,0.00421783,0.001848425,0.001878539,0.000688482,0.0005760388],"domain_scores_gemma":[0.9945427,0.0006100627,0.001677488,0.001731981,0.0008330476,0.000604676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001439787,0.0003215092,0.000009698632,0.4611806,0.525441,0.001240781,0.002002215,2.560909e-7,0.000003699987,0.001366948,0.0007807456,0.00750859],"study_design_scores_gemma":[0.0003622037,0.001431399,0.00001561773,0.02159353,0.8671296,0.004936012,0.0004267997,0.00002834265,0.00001154655,0.00002540009,0.1031616,0.0008779407],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006584996,0.9861099,0.0002544653,0.002034682,0.00001468616,0.01134901,0.00004008641,0.00005509327,0.00007623339],"genre_scores_gemma":[0.0003405591,0.9822243,0.001049942,0.002985312,0.0001034176,0.005520151,0.000994474,0.0001450101,0.006636776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4395871,"threshold_uncertainty_score":0.9994292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.150210934153629,"score_gpt":0.4103321851174895,"score_spread":0.2601212509638604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}