{"id":"W2762476265","doi":"10.1093/annonc/mdx440.031","title":"Pembrolizumab (pembro) versus paclitaxel, docetaxel, or vinflunine for recurrent, advanced urothelial cancer (UC): Mature results from the phase 3 KEYNOTE-045 trial","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Docetaxel; Medicine; Paclitaxel; Urothelial cancer; Internal medicine; Pembrolizumab; Oncology; Phases of clinical research; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001674081,0.0009496459,0.001482487,0.0002332219,0.0003007686,0.0009397558,0.0007228288,0.0008972004,0.004934488],"category_scores_gemma":[0.001573923,0.0003221078,0.001899378,0.0003089525,0.0005342499,0.001266102,0.0003903634,0.003370878,0.0008739446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009013051,"about_ca_system_score_gemma":0.0007963584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048664,"about_ca_topic_score_gemma":0.00375319,"domain_scores_codex":[0.999567,0.0002454421,0.00002021326,0.0000667475,0.00003184422,0.00006872136],"domain_scores_gemma":[0.9995024,0.0001570199,0.0001206762,0.00003649226,0.00002213371,0.000161251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8522146,0.004833813,0.001743478,0.001856833,0.003872186,0.00009593792,0.0001496111,0.002458868,0.005626188,0.0005877361,0.007464051,0.1190967],"study_design_scores_gemma":[0.8800502,0.09711365,0.01000112,0.0002654145,0.002285105,0.000218165,0.0001020858,0.001500041,0.001282716,0.00107796,0.006065701,0.00003779385],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673729,0.01811942,0.0009840349,0.001886584,0.0006384173,0.001168508,0.002354317,0.0002013417,0.007274463],"genre_scores_gemma":[0.9846951,0.00513661,0.001318836,0.001824242,0.000239997,0.0006959467,0.002044721,0.00003683848,0.004007686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004934488,"threshold_uncertainty_score":0.01650751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2148937820526606,"score_gpt":0.4978563534872412,"score_spread":0.2829625714345806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}