{"id":"W2762533155","doi":"","title":"Abstract #1513: Recruitment of histone acetyltransferase activity by the N-terminal homology domain of Pygopus augments TCF-dependent transcriptional activation","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Histone acetyltransferase; CREB-binding protein; Biology; Acetyltransferase; Enhancer; Histone; Molecular biology; Chromatin immunoprecipitation; Transcription (linguistics); Cell biology; Transcription factor; Promoter; Gene; CREB; Genetics; Gene expression; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007897295,0.0002869931,0.0001967039,0.00009560079,0.0001663691,0.0002017292,0.0002214983,0.0002145289,0.008252418],"category_scores_gemma":[0.0001065332,0.0001320342,0.0002442402,0.0001132484,0.0001835592,0.0001367401,0.0003658705,0.0005686962,0.002153548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003173366,"about_ca_system_score_gemma":0.0002112566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006111999,"about_ca_topic_score_gemma":0.0009728182,"domain_scores_codex":[0.9999108,0.000009717764,0.000005819467,0.00002005421,0.00002744083,0.00002607276],"domain_scores_gemma":[0.9999251,0.00001116309,0.0000141584,0.00001057705,0.00000542479,0.00003346465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001746417,0.00001831666,0.00009509805,0.00003315036,0.000002699605,0.00003827836,0.000003750312,0.0000186203,0.9985743,0.00004410895,0.00008927621,0.000907779],"study_design_scores_gemma":[0.00005628268,0.0002441774,0.01255597,0.00001160492,0.00001249273,0.0003532971,0.00001860644,0.0006882212,0.9805966,0.0000524933,0.00540549,0.000004745752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882582,0.001782437,0.002074467,0.0002251547,0.00006880203,0.00003927523,0.001469692,0.0001684723,0.00591351],"genre_scores_gemma":[0.9851769,0.0005346428,0.001849513,0.0001444443,0.00003113162,0.00004408177,0.002495714,0.000051959,0.009671616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008252418,"threshold_uncertainty_score":0.02760708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0687592301962292,"score_gpt":0.4172164125654225,"score_spread":0.3484571823691933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}