{"id":"W2762651948","doi":"10.1093/annonc/mdx367.030","title":"Immune related adverse events (irAEs) in early phase immunotherapy (IO) trials: Implications for recommended phase 2 dose (RP2D) determination","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Discontinuation; Adverse effect; Internal medicine; Gastroenterology; Endocrine system; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1261048,0.0008087114,0.002949386,0.0009886124,0.0006243896,0.003235797,0.001370305,0.001603473,0.0018216],"category_scores_gemma":[0.1284408,0.0004288752,0.003189325,0.001155902,0.0009034768,0.001945325,0.0009236755,0.004428138,0.000431849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001671124,"about_ca_system_score_gemma":0.002161074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004638718,"about_ca_topic_score_gemma":0.001789247,"domain_scores_codex":[0.9184005,0.06616037,0.006763434,0.001772025,0.006196191,0.0007073978],"domain_scores_gemma":[0.7800514,0.1793141,0.02585833,0.004658199,0.008319118,0.001798989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.03411436,0.001371306,0.1377114,0.008165048,0.006845018,0.0002475599,0.0008392787,0.01160333,0.005738554,0.01187229,0.0217867,0.7597051],"study_design_scores_gemma":[0.03047705,0.08556406,0.4984209,0.0131248,0.01817838,0.003951896,0.001598846,0.063361,0.02219047,0.06185783,0.2008269,0.0004477825],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4132529,0.2821547,0.16026,0.04523894,0.005317462,0.00837973,0.005973765,0.001137077,0.0782854],"genre_scores_gemma":[0.9258561,0.009750958,0.04232499,0.01527746,0.001096768,0.002367947,0.001294613,0.0002114065,0.001819836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1261048,"threshold_uncertainty_score":0.6669136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2148737949930711,"score_gpt":0.5153160146034517,"score_spread":0.3004422196103805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}