{"id":"W2762663159","doi":"10.1212/wnl.0000000000004570","title":"A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy","year":2017,"lang":"en","type":"article","venue":"Neurology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Eli Lilly (Canada)","funders":"National Institute on Aging; Italfarmaco; Acceleron; Sanofi; PTC Therapeutics; Parent Project Muscular Dystrophy; AveXis; Biogen; Cedars-Sinai Medical Center; Pfizer; Sarepta Therapeutics; Muscular Dystrophy Association; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Duchenne muscular dystrophy; Placebo; Medicine; Tadalafil; Physical medicine and rehabilitation; Physical therapy; Randomized controlled trial; Muscular dystrophy; Internal medicine; Erectile dysfunction; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004577635,0.0001734181,0.0007588764,0.00004011156,0.0001792546,0.00001133313,0.000355626,0.0002788332,0.0000268403],"category_scores_gemma":[0.001565022,0.0001449752,0.0005128761,0.00001238854,0.0004860999,0.000004152754,0.00008692747,0.00009838324,0.000002777176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001209537,"about_ca_system_score_gemma":0.00006617491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003013566,"about_ca_topic_score_gemma":0.00001518416,"domain_scores_codex":[0.9986544,0.0002827086,0.0003532788,0.0003816715,0.00006175156,0.0002662194],"domain_scores_gemma":[0.9986064,0.0001534627,0.0003858545,0.0007048892,0.00008958677,0.00005984012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8559235,0.000414806,0.000004282474,0.00001268618,0.0002133369,0.000002182284,0.000008724556,0.00002327964,0.1420818,0.0005030888,0.0003250852,0.000487251],"study_design_scores_gemma":[0.9792589,0.006784976,0.00002028849,0.000001191383,0.000135249,0.000003323252,0.000001454313,0.0003525053,0.00778766,0.00102798,0.004506207,0.0001202833],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938092,0.0001325514,0.001350663,0.0006733126,0.0006767738,0.002419272,0.00002156807,0.000008597991,0.0009081099],"genre_scores_gemma":[0.99798,0.00007208411,0.0001375495,0.0004471172,0.0003559231,0.000803297,0.00005777858,0.00001976756,0.0001265003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1342942,"threshold_uncertainty_score":0.5911917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009678021447941122,"score_gpt":0.2812802651911426,"score_spread":0.2716022437432015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}