{"id":"W2762663159","doi":"10.1212/wnl.0000000000004570","title":"A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy","year":2017,"lang":"en","type":"article","venue":"Neurology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Eli Lilly (Canada)","funders":"National Institute on Aging; Italfarmaco; Acceleron; Sanofi; PTC Therapeutics; Parent Project Muscular Dystrophy; AveXis; Biogen; Cedars-Sinai Medical Center; Pfizer; Sarepta Therapeutics; Muscular Dystrophy Association; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Duchenne muscular dystrophy; Placebo; Medicine; Tadalafil; Physical medicine and rehabilitation; Physical therapy; Randomized controlled trial; Muscular dystrophy; Internal medicine; Erectile dysfunction; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002706532,0.001373788,0.003334058,0.0003943759,0.000860628,0.001248735,0.001129173,0.002452912,0.01068722],"category_scores_gemma":[0.002171064,0.0007466133,0.002440324,0.0004011976,0.001221657,0.0007978566,0.0004033043,0.003107622,0.0009984899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008063333,"about_ca_system_score_gemma":0.001835597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676104,"about_ca_topic_score_gemma":0.003724623,"domain_scores_codex":[0.9987274,0.0007020027,0.0000953734,0.0001908422,0.0001169786,0.0001673645],"domain_scores_gemma":[0.9984497,0.0005335057,0.0003288842,0.0001228628,0.0001137179,0.0004514246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9837805,0.007222016,0.0002721753,0.000435568,0.0006519613,0.00002920873,0.00002980079,0.0001030946,0.001717213,0.00005668015,0.0004904577,0.005211268],"study_design_scores_gemma":[0.9727262,0.02589597,0.0007450905,0.00001361682,0.0001554633,0.00000966576,0.00001004643,0.0001053097,0.0001283,0.00004622517,0.0001585545,0.000005513476],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745093,0.004761203,0.001014684,0.001180334,0.001513646,0.01275966,0.001895406,0.0001968784,0.002168847],"genre_scores_gemma":[0.9712862,0.002229369,0.00283001,0.002993665,0.0009600385,0.01595767,0.001079215,0.00002943809,0.002634446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01068722,"threshold_uncertainty_score":0.03575236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009678021447941122,"score_gpt":0.2812802651911426,"score_spread":0.2716022437432015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}