{"id":"W2762666897","doi":"10.1016/j.ajpath.2017.08.032","title":"Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12–Deprivation Optic Neuropathy","year":2017,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health; Research to Prevent Blindness; Université de Montréal; Retina Research Foundation","keywords":"Superoxide; Cobalamin; Optic neuropathy; Optic nerve; Neuroprotection; Superoxide dismutase; Biology; Endocrinology; Internal medicine; Medicine; Chemistry; Vitamin B12; Neuroscience; Biochemistry; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032327,0.0005371832,0.0003411256,0.0005369426,0.0005950783,0.000584857,0.00079985,0.0009286038,0.001965312],"category_scores_gemma":[0.0003343777,0.0002088192,0.0004583533,0.0002429211,0.0004880416,0.0006060439,0.0005433472,0.0008021871,0.0003152132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007005275,"about_ca_system_score_gemma":0.0003912788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001436642,"about_ca_topic_score_gemma":0.001410636,"domain_scores_codex":[0.9997278,0.00005258767,0.00004030706,0.00005138119,0.0000597435,0.00006828801],"domain_scores_gemma":[0.9997305,0.00002447082,0.00008063891,0.0000373297,0.00007467069,0.00005228218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001062316,0.0001566118,0.005926809,0.0002951343,0.00007738531,0.00211602,0.0002160526,0.000075439,0.9806737,0.001897141,0.0005450137,0.006958362],"study_design_scores_gemma":[0.0001561911,0.001218278,0.04175469,0.00007051549,0.0002247906,0.008018556,0.0007172746,0.002586073,0.9327437,0.002612938,0.009860951,0.00003593619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977309,0.008627176,0.00896387,0.001159232,0.0002687721,0.00009802464,0.0003582147,0.0001802958,0.003035394],"genre_scores_gemma":[0.9945968,0.00100524,0.001945765,0.0001225453,0.00003735615,0.00003476037,0.0001715988,0.000008909782,0.002077075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965312,"threshold_uncertainty_score":0.006574631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241217710984599,"score_gpt":0.2702214767407278,"score_spread":0.2578092996308818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}