{"id":"W2762702152","doi":"10.2217/epi-2017-0038","title":"Homocysteine Levels Associate With Subtle Changes in Leukocyte DNA Methylation: An Epigenome-Wide Analysis","year":2017,"lang":"en","type":"article","venue":"Epigenomics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Public Health Ontario; University of Toronto","funders":"European Regional Development Fund; Canadian Institutes of Health Research; Centre for Medical Systems Biology; Tartu Ülikool; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Erasmus Medisch Centrum; ZonMw; Agence Nationale de la Recherche; European Commission; Eesti Teadusagentuur; Heart and Stroke Foundation of Canada","keywords":"DNA methylation; Biology; Epigenome; Epigenetics; Methylation; Genetics; Differentially methylated regions; Homocysteine; Molecular biology; Bisulfite sequencing; DNA; Gene; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009999264,0.0002200752,0.0006543122,0.0005344793,0.0003615641,0.0001516869,0.0003633726,0.0001563787,0.0002216851],"category_scores_gemma":[0.000182135,0.0001840495,0.0001193922,0.0004541334,0.0001291711,0.0002493207,0.0001093656,0.0003057106,0.000078906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000392976,"about_ca_system_score_gemma":0.0002234046,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059429,"about_ca_topic_score_gemma":0.02092945,"domain_scores_codex":[0.9982207,0.00009674225,0.0002979209,0.0004598011,0.0003793353,0.0005454706],"domain_scores_gemma":[0.9981399,0.00009390948,0.0002300462,0.001112891,0.000179287,0.0002439219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005828675,0.0003447276,0.9597784,0.00007590836,0.001792416,0.0005596246,0.002130958,0.0002556035,0.01644955,0.000103763,0.00004963187,0.01787649],"study_design_scores_gemma":[0.001656805,0.000537774,0.9734299,0.00002721584,0.0004249693,0.000003699705,0.0001905426,0.0007687511,0.01924327,0.0000758742,0.003383036,0.0002582025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935679,0.0003847117,0.0002527407,0.001944155,0.00005646086,0.0003848693,0.00003929593,0.00003612143,0.003333675],"genre_scores_gemma":[0.9929383,0.0002229524,0.0008649424,0.0001556022,0.0002086213,0.00002380582,0.000114005,0.00004285171,0.005428953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01987003,"threshold_uncertainty_score":0.996936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06098408283608522,"score_gpt":0.3400893167568655,"score_spread":0.2791052339207803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}