{"id":"W2762704796","doi":"10.1093/eep/dvx015","title":"Maintenance of Mest imprinted methylation in blastocyst-stage mouse embryos is less stable than other imprinted loci following superovulation or embryo culture","year":2017,"lang":"en","type":"review","venue":"Current Zoology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"","keywords":"Genomic imprinting; Methylation; Blastocyst; Biology; Imprinting (psychology); DNA methylation; Andrology; Embryo; Insulin-like growth factor 2 receptor; Epigenetics; Embryo culture; Genetics; Embryogenesis; Gene; Growth factor; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005023057,0.0006176251,0.00158713,0.0001914124,0.0001052072,0.00004759604,0.0007011958,0.0008085892,0.00007388054],"category_scores_gemma":[0.0003543323,0.0004928767,0.0006639738,0.0001854294,0.0001273645,0.00001534693,0.0004459868,0.0004875315,0.00001803561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009132797,"about_ca_system_score_gemma":0.0003474289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181006,"about_ca_topic_score_gemma":0.0003591054,"domain_scores_codex":[0.9968431,0.0002956745,0.001097721,0.0009474158,0.0001972176,0.0006188675],"domain_scores_gemma":[0.9976023,0.0000348802,0.001009144,0.001083328,0.0001669503,0.0001033571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001008236,0.000442391,0.003897096,0.01363767,0.001008622,0.00001585569,0.0005753763,0.00005798094,0.04587594,0.0001223608,0.0004401994,0.9338257],"study_design_scores_gemma":[0.001725549,0.0004000233,0.001016878,0.004068308,0.0004584227,0.00005736476,0.0002503907,0.0003022673,0.007073943,0.00002146443,0.9835468,0.001078607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08524142,0.9075807,0.004085202,0.00001429542,0.001112501,0.001504754,0.0002058,0.0000254085,0.0002299333],"genre_scores_gemma":[0.02447001,0.9670557,0.0005249255,0.00002054749,0.0002211647,0.0001814057,0.0007805959,0.000142269,0.006603415],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9831066,"threshold_uncertainty_score":0.9997523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08081879887219379,"score_gpt":0.3688625839421011,"score_spread":0.2880437850699074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}