{"id":"W2762766132","doi":"10.3390/pharmaceutics9040045","title":"Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids","year":2017,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Waterloo; University of Manitoba","funders":"Ciência sem Fronteiras; Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; Kuwait University; Research Manitoba","keywords":"Disposition; Histone deacetylase; Metabolism; Chemistry; Pharmacology; Histone acetyltransferase; Biochemistry; Acetylation; Histone; Biology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214201,0.0002738404,0.000174663,0.000397187,0.0001291227,0.0001611612,0.00009500391,0.0002005264,0.001314525],"category_scores_gemma":[0.0002191395,0.0001324109,0.0002524738,0.000236765,0.0001252938,0.0001364795,0.00008508687,0.0002459682,0.000361844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003297498,"about_ca_system_score_gemma":0.000341644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003303206,"about_ca_topic_score_gemma":0.005365031,"domain_scores_codex":[0.9999084,0.00001249315,0.000007495322,0.00002952534,0.00002398947,0.0000180379],"domain_scores_gemma":[0.9998734,0.00001160824,0.00005367484,0.00001723271,0.00002720189,0.00001692818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005269767,0.00004267565,0.002494189,0.0001096704,0.00004338049,0.00005778499,0.00002089025,0.00007085037,0.9869952,0.000043214,0.0001026334,0.009492608],"study_design_scores_gemma":[0.00001446709,0.0007061035,0.02117281,0.000009525009,0.00007919357,0.0003076079,0.00001884217,0.000343348,0.9737569,0.00002878046,0.003550852,0.00001156809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824429,0.009249474,0.005247941,0.0001159487,0.0000454093,0.00006692614,0.001404352,0.0001223939,0.001304682],"genre_scores_gemma":[0.9861392,0.003303905,0.004887365,0.00006226824,0.00001432118,0.00005401607,0.0008573605,0.00002470702,0.004656792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003303206,"threshold_uncertainty_score":0.006567955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02340131881577388,"score_gpt":0.3445530849207114,"score_spread":0.3211517661049375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}