{"id":"W2762766132","doi":"10.3390/pharmaceutics9040045","title":"Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids","year":2017,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Waterloo; University of Manitoba","funders":"Ciência sem Fronteiras; Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; Kuwait University; Research Manitoba","keywords":"Disposition; Histone deacetylase; Metabolism; Chemistry; Pharmacology; Histone acetyltransferase; Biochemistry; Acetylation; Histone; Biology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610345,0.0001522036,0.000165571,0.00003663352,0.0002283041,0.00003663305,0.00008593289,0.000120426,0.00000988829],"category_scores_gemma":[0.00004967404,0.0001508652,0.00003115717,0.00003340673,0.0007145458,0.0000162804,0.0001266051,0.0001104005,8.58128e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007311732,"about_ca_system_score_gemma":0.00002297254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005450633,"about_ca_topic_score_gemma":0.00002084322,"domain_scores_codex":[0.9992301,0.00003386569,0.0001554943,0.0003100611,0.0001106223,0.0001598214],"domain_scores_gemma":[0.9993445,0.00001846462,0.0001059916,0.0003033826,0.00004536712,0.0001823152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006784034,0.0001054064,0.001812918,0.00007698071,0.0000398821,0.000001147399,0.0001077924,2.561456e-7,0.9821123,0.0002890889,0.0001208526,0.01526551],"study_design_scores_gemma":[0.001258444,0.00004798761,0.009472638,0.0000151968,0.0001276927,0.00004318948,0.00001756434,0.0002129144,0.9551823,0.0001716505,0.03327202,0.0001784376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941359,0.001798279,0.002470753,0.0009467433,0.00004362707,0.0002297482,0.0001882327,0.000009542588,0.0001771808],"genre_scores_gemma":[0.9981393,0.0009618999,0.0003992906,0.0002279005,0.0001080371,0.00002581724,0.00002647358,0.00001894797,0.00009229845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03315116,"threshold_uncertainty_score":0.6152103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02340131881577388,"score_gpt":0.3445530849207114,"score_spread":0.3211517661049375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}