{"id":"W2762812418","doi":"10.1093/annonc/mdx386.002","title":"Initial results of BMS-986012, a first-in-class fucosyl-GM1 mAb, in combination with nivolumab, in pts with relapsed/refractory (rel/ref) small-cell lung cancer (SCLC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre; University of Alberta; Alberta Health Services","funders":"","keywords":"Medicine; Tolerability; Nivolumab; Internal medicine; Refractory (planetary science); Oncology; Toxicity; Lung cancer; Pharmacology; Gastroenterology; Cancer; Adverse effect; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008624742,0.001263621,0.002413639,0.0004629307,0.0005813426,0.0009455289,0.0005359256,0.0009393767,0.002133637],"category_scores_gemma":[0.001007249,0.0003687211,0.001578614,0.0005087672,0.0006112095,0.0007043745,0.0003102648,0.003050363,0.0008257338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000818438,"about_ca_system_score_gemma":0.0008430146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001987159,"about_ca_topic_score_gemma":0.006064908,"domain_scores_codex":[0.9996458,0.0001502439,0.00002855654,0.00004127142,0.00003466154,0.00009932351],"domain_scores_gemma":[0.9995055,0.0001435667,0.0000402648,0.00003447172,0.00003691676,0.0002391787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4423465,0.05777178,0.01624137,0.001127528,0.002306399,0.001723452,0.0009124544,0.005983842,0.1400691,0.0003325352,0.005351534,0.3258335],"study_design_scores_gemma":[0.1161887,0.7404293,0.06825725,0.0001230519,0.003576976,0.00195136,0.0003531859,0.004228562,0.0518098,0.000363607,0.01261511,0.0001031456],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896538,0.003409836,0.0004792071,0.0006032187,0.0001574047,0.000734993,0.0008029358,0.0001360412,0.004022612],"genre_scores_gemma":[0.9930997,0.00172386,0.0008731815,0.0004675355,0.0002018384,0.0002912864,0.001298814,0.00004069171,0.002002986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002413639,"threshold_uncertainty_score":0.007137716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04583309178589952,"score_gpt":0.3634510832496083,"score_spread":0.3176179914637088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}