{"id":"W2762965851","doi":"10.1089/scd.2017.0090","title":"Optimizing Human Induced Pluripotent Stem Cell Expansion in Stirred-Suspension Culture","year":2017,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Induced pluripotent stem cell; Biology; Bioreactor; Embryonic stem cell; Human Induced Pluripotent Stem Cells; Regenerative medicine; Germ layer; Suspension culture; Seeding; Chemically defined medium; Suspension (topology); Cell culture; Cell biology; Biotechnology; Stem cell; Botany; In vitro; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003432949,0.0002882809,0.0002648089,0.00008622805,0.000620987,0.0001791533,0.0003898335,0.0002507841,0.00001022133],"category_scores_gemma":[0.000002557415,0.0002522569,0.00004969404,0.00004042486,0.00006202448,0.00001630761,0.0007421024,0.0002105887,0.00003033787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006736942,"about_ca_system_score_gemma":0.0001438452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004924735,"about_ca_topic_score_gemma":0.0001438756,"domain_scores_codex":[0.998024,0.00007315122,0.0003819322,0.0006859988,0.0003447952,0.0004901423],"domain_scores_gemma":[0.9989296,0.000006385018,0.0001810003,0.0005948123,0.00008708963,0.000201088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005427351,0.00008885923,0.001469906,0.00009899136,0.00001697841,0.00004792799,0.0006487759,0.00004420837,0.9854309,0.000003680082,0.0004878351,0.01160765],"study_design_scores_gemma":[0.001294284,0.0001670447,0.004497263,0.0001174103,0.000004897585,0.000007319456,0.000835411,0.00004799211,0.9726316,0.000004133658,0.0200139,0.0003786932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962983,0.0008564753,0.0001268323,0.00006491329,0.0002070133,0.0004506593,0.000004384854,0.00001345009,0.00197803],"genre_scores_gemma":[0.991982,0.0004601608,0.001373678,0.00004718584,0.00006169929,0.0000324105,0.00003505572,0.00003217592,0.005975598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01952607,"threshold_uncertainty_score":0.999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0312588455918848,"score_gpt":0.2739688865430893,"score_spread":0.2427100409512045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}