{"id":"W2762992799","doi":"10.1101/gad.301093.117","title":"Two distinct transcription termination modes dictated by promoters","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; Office of Research Infrastructure Programs, National Institutes of Health; National Institute for Health and Care Research; Friedrich Miescher Institute for Biomedical Research; National Research Foundation; Universität Basel; Albert-Ludwigs-Universität Freiburg; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; National Institutes of Health; National Science Foundation","keywords":"Biology; RNA polymerase II; Promoter; Polyadenylation; Genetics; Termination factor; Gene; Transcription (linguistics); Exoribonuclease; Cell biology; RNA polymerase; RNA; Gene expression; RNase P","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001607362,0.0001064743,0.00007464211,0.00002283163,0.0003701392,0.00008405416,0.000219518,0.00004893408,0.000009179969],"category_scores_gemma":[0.00002597524,0.00009639241,0.00002954503,0.00001542066,0.00004839466,0.000008260869,0.00006406927,0.00003862155,0.00001066951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002637223,"about_ca_system_score_gemma":0.00007801379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004198132,"about_ca_topic_score_gemma":0.00008683134,"domain_scores_codex":[0.9992208,0.00002295669,0.0001349038,0.0002447156,0.0001507383,0.0002259165],"domain_scores_gemma":[0.9995584,0.000001718376,0.00005995343,0.0002479584,0.00005380046,0.00007817033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002934836,0.00002459129,0.004289126,0.00001041976,0.00002182563,0.000002181484,0.00005051347,0.000003661809,0.8566531,0.000004226797,0.0004075922,0.1385034],"study_design_scores_gemma":[0.0005129122,0.00005552965,0.04207753,0.0000152063,0.000004556497,0.000004072093,0.00002746669,0.0002976093,0.9346144,0.00001594167,0.02221564,0.000159201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955018,0.0002518387,0.003102013,0.0001840437,0.0000624423,0.0001711328,0.000007296983,0.00001146175,0.0007079791],"genre_scores_gemma":[0.9947522,0.0001090825,0.001905006,0.00003258774,0.00004837861,0.00004809445,0.0002792706,0.00001276071,0.002812583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1383442,"threshold_uncertainty_score":0.3930768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568626098392849,"score_gpt":0.286400583903856,"score_spread":0.2707143229199275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}