{"id":"W2763023265","doi":"10.3390/cancers9100137","title":"STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line","year":2017,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Cisplatin; CD44; Cancer research; Hypoxia (environmental); STAT3; Gene knockdown; Clonogenic assay; Chemistry; Transcription factor; Cancer cell; Biology; Apoptosis; Cell; Cancer; Biochemistry; Chemotherapy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035781,0.0001611115,0.0002251446,0.0001575148,0.0001809027,0.0003016766,0.00008557085,0.0001912673,0.001473292],"category_scores_gemma":[0.00007976682,0.0001146549,0.0002886191,0.0001892123,0.0001403567,0.0001738439,0.0001041522,0.0004242431,0.0004401199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002747919,"about_ca_system_score_gemma":0.0002745594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186837,"about_ca_topic_score_gemma":0.001373341,"domain_scores_codex":[0.9998975,0.00001232826,0.00001023625,0.0000137446,0.00003242435,0.00003372705],"domain_scores_gemma":[0.9999501,0.000006709809,0.00001427945,0.000004777136,0.00001014073,0.00001402531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658879,0.00002404787,0.0007767725,0.00008082711,0.00000745104,0.00008150939,0.00002794211,0.00007638193,0.9969536,0.0001379002,0.000207366,0.001460218],"study_design_scores_gemma":[0.00006358687,0.000473528,0.05006686,0.00003099562,0.00008083196,0.00109009,0.0001801618,0.003639703,0.9308372,0.0002321541,0.01328939,0.00001548626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868783,0.006088936,0.002634932,0.0004902823,0.00008352203,0.00002697455,0.001477342,0.0001204357,0.002199278],"genre_scores_gemma":[0.9948398,0.001424935,0.0006420259,0.0001504361,0.00001304238,0.00002244484,0.001279002,0.000009809,0.001618474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001473292,"threshold_uncertainty_score":0.004928589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572829475218248,"score_gpt":0.27486497535896,"score_spread":0.2591366806067776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}