{"id":"W2763173694","doi":"10.1016/s2215-0366(17)30371-1","title":"Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial","year":2017,"lang":"en","type":"article","venue":"The Lancet Psychiatry","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":556,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; Centre for Addiction and Mental Health; University of British Columbia","funders":"Janssen Pharmaceuticals; National Institute on Drug Abuse; Brain and Behavior Research Foundation; Medtronic; Defense Advanced Research Projects Agency; H. Lundbeck A/S; NeuroPace; Canadian Institutes of Health Research; Jazz Pharmaceuticals; Stanley Foundation; Boston Scientific Corporation; Allergan; Biotronik; National Institute of Neurological Disorders and Stroke; Takeda Pharmaceutical Company; Hope for Depression Research Foundation; National Institutes of Health; A. Alfred Taubman Medical Research Institute; Pfizer; Baxter International; GlaxoSmithKline; National Institute of Mental Health; American Epilepsy Society; St. Jude Medical; Rare Disease Foundation; National Institute on Aging; Abbott Laboratories; GE Global Research; National Science Foundation","keywords":"Depression (economics); Deep brain stimulation; Medicine; Treatment-resistant depression; Adverse effect; Randomized controlled trial; White matter; Clinical trial; Clinical endpoint; Major depressive disorder; Internal medicine; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719875,0.0002482494,0.0008762045,0.00003289221,0.0006662102,0.00008711954,0.0002182422,0.0001199284,0.00007078369],"category_scores_gemma":[0.0003528215,0.0001248229,0.0004306293,0.00003197353,0.00007087317,0.00006642918,0.00003276192,0.00009236443,0.00001512136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002643696,"about_ca_system_score_gemma":0.00004593689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004168438,"about_ca_topic_score_gemma":0.000171779,"domain_scores_codex":[0.998648,0.0001021268,0.0003442813,0.0003638231,0.0001849085,0.0003568566],"domain_scores_gemma":[0.9983023,0.0003872598,0.0003010262,0.000867943,0.0000369933,0.0001044962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9603046,0.0008949604,0.03070652,0.00002656598,0.0004398455,0.00001708571,0.00007260557,0.00001886962,0.0002693588,0.0003339208,0.001731171,0.005184456],"study_design_scores_gemma":[0.9165582,0.001995526,0.07082432,0.00003855459,0.0005818158,0.000004181873,0.00001426289,0.002639681,0.00002281724,0.006650135,0.0005372634,0.0001332317],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688669,0.0008057461,0.0003875437,0.0193476,0.001037845,0.007078832,0.00002526167,0.00009004366,0.00236027],"genre_scores_gemma":[0.9933091,0.00004513005,0.001186443,0.001892037,0.001679793,0.0008587718,0.00004201601,0.00002992338,0.0009567562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04374642,"threshold_uncertainty_score":0.5124018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03415864956645984,"score_gpt":0.3378132582723619,"score_spread":0.303654608705902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}