{"id":"W2763217028","doi":"10.1111/bpa.12567","title":"Downregulated apoptosis and autophagy after anti‐Aβ immunotherapy in Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Fondation Philippe Chatrier; Fondation Philippe Wiener - Maurice Anspach; University of Southampton; Medical Research Council Canada; University Hospital Southampton NHS Foundation Trust; Johns Hopkins University","keywords":"Autophagy; Apoptosis; Immunotherapy; Disease; Medicine; Alzheimer's disease; Cancer research; Immunology; Biology; Pathology; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002022114,0.0002149845,0.0004009889,0.0001447815,0.0001514288,0.00004122705,0.0001664716,0.0001668071,0.0003603462],"category_scores_gemma":[0.00009386852,0.0001875839,0.00009679427,0.00005611038,0.0003780618,0.0001286373,0.00007733955,0.0001673031,0.0000445057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001781386,"about_ca_system_score_gemma":0.00007723613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002803796,"about_ca_topic_score_gemma":0.000004058325,"domain_scores_codex":[0.9987489,0.0001023502,0.0002524616,0.0004231133,0.0001194422,0.000353733],"domain_scores_gemma":[0.9987229,0.00005481977,0.0001132465,0.0008633128,0.00003310287,0.0002126629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008337872,0.001754471,0.6003133,0.0001372008,0.0008779083,0.0136987,0.002396838,0.000006578866,0.1914346,0.002503448,0.00201152,0.1765275],"study_design_scores_gemma":[0.003707949,0.0001355833,0.9872287,0.00005870047,0.00008185924,0.00008616113,0.00001690105,0.00009113307,0.005476139,0.001335839,0.001586265,0.0001947924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865591,0.007752696,0.0000230755,0.004547837,0.0001767176,0.0003927963,0.00002388907,0.00006746579,0.0004564103],"genre_scores_gemma":[0.9947495,0.0004859102,0.0001709381,0.004041131,0.0001110168,0.00009489014,0.00002362749,0.00003788318,0.0002850524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3869154,"threshold_uncertainty_score":0.7649451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380374852623055,"score_gpt":0.2958427992337521,"score_spread":0.2820390507075216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}