{"id":"W2763401475","doi":"10.1172/jci93437","title":"Proprotein convertase furin regulates osteocalcin and bone endocrine function","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut de Readaptation Gingras Lindsay de Montreal; McGill University; Université du Québec; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canadian Diabetes Association; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke; Johns Hopkins University; Université de Montréal","keywords":"Furin; Osteocalcin; Endocrinology; Proprotein convertase; Internal medicine; Chemistry; Proprotein Convertases; Osteoblast; Biology; Biochemistry; Alkaline phosphatase; Lipoprotein; In vitro; Cholesterol; Medicine; LDL receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00225032,0.0001105276,0.0005325258,0.00009903443,0.0002157724,0.00006981762,0.00009331605,0.00009893726,0.00003191804],"category_scores_gemma":[0.0144124,0.00007487522,0.0001347458,0.00003726407,0.0006540071,0.000367096,0.00009693181,0.0005573186,0.00001222443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002612421,"about_ca_system_score_gemma":0.0001757874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002190129,"about_ca_topic_score_gemma":0.00001024897,"domain_scores_codex":[0.9980049,0.0001599519,0.001035577,0.0001627703,0.0004738337,0.0001629591],"domain_scores_gemma":[0.9974157,0.0003012856,0.001067934,0.0003018535,0.0005428933,0.0003702873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002200889,0.0003864621,0.7996139,0.0005670401,0.0005363443,0.0007080156,0.0002230444,0.000004178152,0.04893491,0.0007644451,0.01200738,0.1340534],"study_design_scores_gemma":[0.0041579,0.002436486,0.9650857,0.0004800689,0.0001746543,0.0002620464,0.00007366906,0.0002838528,0.02096618,0.004449736,0.001549807,0.00007989008],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805697,0.0005437594,0.000065508,0.01792173,0.000338061,0.0002877338,0.000001405912,0.00001112759,0.0002609846],"genre_scores_gemma":[0.9953799,0.0004143815,0.001817335,0.0003443747,0.0009203479,0.000005218087,0.000002907359,0.00001135282,0.001104158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1654718,"threshold_uncertainty_score":0.9938896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.110902220689382,"score_gpt":0.4236542309173333,"score_spread":0.3127520102279513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}