{"id":"W2763494323","doi":"10.1093/annonc/mdx389.003","title":"Overall survival (OS) and forced vital capacity (FVC) results from the LUME-Meso study of nintedanib (N) + pemetrexed/cisplatin (PEM/CIS) vs placebo (P) + PEM/CIS in chemo-naïve patients (pts) with malignant pleural mesothelioma (MPM)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Hazard ratio; Placebo; Interim analysis; Gastroenterology; Progression-free survival; Pemetrexed; Confidence interval; Phases of clinical research; Urology; Surgery; Toxicity; Clinical trial; Chemotherapy; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001435537,0.0008085265,0.001682481,0.0003036877,0.0002757188,0.0006449949,0.0005798733,0.0008754744,0.00192903],"category_scores_gemma":[0.0007945006,0.0003782889,0.002206409,0.0002833496,0.0006648308,0.000768398,0.0003707259,0.00175789,0.0002939594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000549029,"about_ca_system_score_gemma":0.0004721514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008657112,"about_ca_topic_score_gemma":0.001931897,"domain_scores_codex":[0.9995471,0.000234478,0.00003610279,0.00007300256,0.00003886088,0.00007043779],"domain_scores_gemma":[0.9993766,0.0001783148,0.0001103016,0.00005141406,0.00002713597,0.0002562669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.943941,0.004140508,0.01759353,0.0005285901,0.003194757,0.00009954155,0.00009020075,0.001054074,0.007645761,0.0000837238,0.000848177,0.02078019],"study_design_scores_gemma":[0.3709224,0.4526838,0.1625772,0.0001014607,0.007232679,0.0002577293,0.0001386818,0.001291973,0.002400938,0.0002527785,0.002081721,0.0000587507],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942141,0.003831448,0.00009714432,0.0001662257,0.00007298464,0.0001237891,0.0008109505,0.00001263599,0.0006707083],"genre_scores_gemma":[0.9964103,0.001123666,0.0001130916,0.0002122114,0.0001120463,0.0001395613,0.00120666,0.000004554679,0.000677851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192903,"threshold_uncertainty_score":0.007591903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06856131402586725,"score_gpt":0.3329019613771992,"score_spread":0.264340647351332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}