{"id":"W2763542963","doi":"10.1128/cvi.00273-17","title":"A Single Intramuscular Dose of a Plant-Made Virus-Like Particle Vaccine Elicits a Balanced Humoral and Cellular Response and Protects Young and Aged Mice from Influenza H1N1 Virus Challenge despite a Modest/Absent Humoral Response","year":2017,"lang":"en","type":"article","venue":"Clinical and Vaccine Immunology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Ministère de l'Économie, des Finances et de l'Industrie; Government of Canada","keywords":"Virus-like particle; Vaccination; Virus; Hemagglutinin (influenza); Immune system; Immunology; Virology; Humoral immunity; Splenocyte; Antibody; Nasal administration; Biology; Influenza vaccine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068076,0.0004940522,0.0003940899,0.00028142,0.00009600359,0.0001596611,0.0001806882,0.0004143394,0.000906716],"category_scores_gemma":[0.00009433686,0.0001825599,0.0002790837,0.00009400953,0.0002479898,0.000286291,0.000136999,0.0007635877,0.0002852956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001869347,"about_ca_system_score_gemma":0.0001448393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393335,"about_ca_topic_score_gemma":0.0005326251,"domain_scores_codex":[0.9998689,0.00001155828,0.0000124352,0.00004137648,0.00002330779,0.00004239585],"domain_scores_gemma":[0.9998216,0.00001278311,0.00006031751,0.00001529886,0.00001762273,0.00007244551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000535999,0.0001865466,0.0004029711,0.00002843922,0.000005279901,0.00002393603,0.00001349325,0.00003950172,0.9977068,0.00001650149,0.00002916841,0.001011367],"study_design_scores_gemma":[0.0001744367,0.02555015,0.02919701,0.00002506159,0.000060772,0.0004812793,0.0000906517,0.0008645272,0.941768,0.00007135489,0.001702168,0.00001455704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978802,0.0004855598,0.0008041697,0.0000330162,0.00002681919,0.0000405194,0.0002451637,0.00005901518,0.0004256793],"genre_scores_gemma":[0.9956797,0.0003823987,0.001300055,0.00009943558,0.00002413625,0.00006735986,0.0004457668,0.00001326658,0.001987749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000906716,"threshold_uncertainty_score":0.003033221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1061324551089812,"score_gpt":0.3811166134978372,"score_spread":0.274984158388856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}