{"id":"W2763599687","doi":"10.1073/pnas.1713625114","title":"WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universiteit Utrecht; École Polytechnique Fédérale de Lausanne; Institute of Genetics; Institut National de la Santé et de la Recherche Médicale; Fondation Fyssen; Agence Nationale de la Recherche; Medical Research Council; Centre National de la Recherche Scientifique; South African Medical Research Council","keywords":"Biology; Lissencephaly; Microcephaly; Cell biology; Neurogenesis; Autophagy; Microtubule-associated protein; Neural development; Microtubule; Neuroscience; Phenotype; Neural stem cell; Gene; Genetics; Stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008463513,0.0000658031,0.00008168963,0.00003428697,0.0003978287,0.00004288821,0.0003855072,0.00009316255,0.000001618339],"category_scores_gemma":[0.0007744619,0.00004910338,0.00004117539,0.00004804556,0.000356911,0.00001554116,0.0001546158,0.00003672388,1.225981e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008254912,"about_ca_system_score_gemma":0.00004511339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003575118,"about_ca_topic_score_gemma":3.049179e-7,"domain_scores_codex":[0.9992144,0.000003297091,0.0001814356,0.0002037312,0.0002946564,0.0001024689],"domain_scores_gemma":[0.9993291,0.00001435432,0.0003943505,0.00001090052,0.0002292675,0.0000220004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001182935,0.00001876159,0.002041636,0.00002602142,0.00001624148,9.143151e-10,0.00007360356,0.000001629506,0.9954795,0.001199035,0.0002756546,0.0008560586],"study_design_scores_gemma":[0.0002345626,0.00005088283,0.03910432,0.00003290483,0.000004635153,4.191152e-7,0.00001553698,0.000116592,0.9518921,0.006419807,0.002068223,0.00005998619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963319,0.000229441,0.00001270072,0.002494234,0.00001154464,0.0002511931,0.00001378748,0.000001855218,0.0006532845],"genre_scores_gemma":[0.995711,0.00001621388,0.003466216,0.0001297796,0.00004529602,0.00002189295,7.13976e-7,0.000003468815,0.0006054573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0435874,"threshold_uncertainty_score":0.3059817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03145566910645069,"score_gpt":0.3191972064097224,"score_spread":0.2877415373032717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}