{"id":"W2763599687","doi":"10.1073/pnas.1713625114","title":"WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universiteit Utrecht; École Polytechnique Fédérale de Lausanne; Institute of Genetics; Institut National de la Santé et de la Recherche Médicale; Fondation Fyssen; Agence Nationale de la Recherche; Medical Research Council; Centre National de la Recherche Scientifique; South African Medical Research Council","keywords":"Biology; Lissencephaly; Microcephaly; Cell biology; Neurogenesis; Autophagy; Microtubule-associated protein; Neural development; Microtubule; Neuroscience; Phenotype; Neural stem cell; Gene; Genetics; Stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007037832,0.0003317242,0.0002008783,0.0003297048,0.0001732054,0.000205205,0.0001566882,0.0001804282,0.0008924072],"category_scores_gemma":[0.0000657594,0.0001051079,0.0001839271,0.0001849294,0.0002341791,0.00007898959,0.0002126261,0.0002437892,0.000336582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551969,"about_ca_system_score_gemma":0.0002445609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000946222,"about_ca_topic_score_gemma":0.002021603,"domain_scores_codex":[0.9999398,0.00000829632,0.0000058245,0.00001671617,0.00001661502,0.00001281248],"domain_scores_gemma":[0.9999398,0.00000885973,0.00002340875,0.00000760924,0.000003665137,0.00001669338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003746946,0.000005377845,0.0004031898,0.00002235732,0.000007436787,0.0001355191,0.0000069804,0.00005736089,0.9977937,0.0001424633,0.00003213315,0.001355894],"study_design_scores_gemma":[0.000005832877,0.00007015368,0.0120495,0.000006741619,0.00002714446,0.0007628285,0.00002291822,0.001081283,0.9813824,0.0001089118,0.004477638,0.000004650198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932228,0.001361015,0.002613154,0.00007025052,0.00001954699,0.000007967304,0.0007476,0.0001503769,0.0018073],"genre_scores_gemma":[0.9936966,0.0007369149,0.001211258,0.00002204653,0.000003601146,0.000008764512,0.001395642,0.00002683099,0.002898348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000946222,"threshold_uncertainty_score":0.002985358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03145566910645069,"score_gpt":0.3191972064097224,"score_spread":0.2877415373032717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}