{"id":"W2763751953","doi":"10.1158/2159-8290.cd-17-0698","title":"Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1364,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Juno Therapeutics","keywords":"Neurotoxicity; Medicine; Cytokine release syndrome; Immunology; Bone marrow; Blood–brain barrier; Pericyte; Endothelium; Chimeric antigen receptor; Cancer research; Immunotherapy; Endothelial stem cell; Internal medicine; Central nervous system; Immune system; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003079513,0.0007722662,0.001094599,0.001021493,0.0007692222,0.00190897,0.001518771,0.009621013,0.00300289],"category_scores_gemma":[0.004809695,0.0004041957,0.0008564272,0.0008475471,0.001516897,0.001169175,0.0009096214,0.01409364,0.001871963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003645194,"about_ca_system_score_gemma":0.002487114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007923318,"about_ca_topic_score_gemma":0.01080217,"domain_scores_codex":[0.9985103,0.0004709313,0.0001132152,0.0002815129,0.0004675197,0.0001565305],"domain_scores_gemma":[0.9965102,0.001984771,0.0002919708,0.00009550216,0.0008923509,0.0002251043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001020447,0.0001686352,0.002304641,0.001369527,0.0001983608,0.001650567,0.0002077975,0.0002387348,0.003600594,0.003389147,0.8654999,0.1203517],"study_design_scores_gemma":[0.000800859,0.0007806738,0.01869698,0.003718309,0.0004407282,0.002297348,0.0003195995,0.000806917,0.003472647,0.005841668,0.9626762,0.0001481782],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.007518517,0.4232429,0.0006043119,0.4862315,0.07027319,0.0001236578,0.0006869402,0.0002105647,0.01110847],"genre_scores_gemma":[0.06331016,0.3552394,0.0005584981,0.4028576,0.1501054,0.0003457695,0.0006228997,0.0001241869,0.02683607],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009621013,"threshold_uncertainty_score":0.02644789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706914031407214,"score_gpt":0.3043987147974286,"score_spread":0.2873295744833565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}