{"id":"W2763755836","doi":"10.1093/annonc/mdx365.011","title":"Impact of prior treatment on palbociclib plus letrozole (P+L) efficacy and safety in patients (pts) with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2–) first-line advanced breast cancer (ABC): A PALOMA-2 subgroup analysis","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; McGill University Health Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Palbociclib; Adverse effect; Neutropenia; Progression-free survival; Letrozole; Adjuvant; Discontinuation; Oncology; Chemotherapy; Gastroenterology; Surgery; Gynecology; Clinical trial; Metastatic breast cancer; Breast cancer; Cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001684116,0.0005231863,0.001866234,0.0003901312,0.0002186579,0.0000139376,0.0002352934,0.0002135127,0.0002717576],"category_scores_gemma":[0.000148788,0.000380483,0.0003494539,0.0003620693,0.0006761618,0.0003060438,0.00008275562,0.0002587567,0.000002756359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126166,"about_ca_system_score_gemma":0.0003844322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004699295,"about_ca_topic_score_gemma":0.001986756,"domain_scores_codex":[0.9973693,0.0002032666,0.0007776,0.0006891328,0.0003578275,0.0006028709],"domain_scores_gemma":[0.9967327,0.0004046143,0.001287652,0.0006472747,0.0006318159,0.0002960159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04078648,0.002650928,0.7422572,0.00007223418,0.003988051,0.00002284177,0.00180483,0.0005437943,0.001555483,0.00003384736,0.00001694654,0.2062674],"study_design_scores_gemma":[0.02827055,0.02147755,0.9416609,0.0003200573,0.0004460339,0.000007235686,0.00008568119,0.0000277294,0.007224362,0.00002289202,0.0001553683,0.0003015737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950495,0.0002474334,0.00003226922,0.001834928,0.00005718628,0.001249862,0.001359957,0.00003297155,0.0001358998],"genre_scores_gemma":[0.9979579,0.0008036816,0.0006202009,0.0001230322,0.00009915631,0.0001239151,0.0001522327,0.00006912645,0.00005068729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2059658,"threshold_uncertainty_score":0.9998647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03404481043125903,"score_gpt":0.375483825991651,"score_spread":0.341439015560392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}